Description

tert-Butyl 2-(Chloromethyl)-5,8-dihydropyrido[3,4-d]pyrimidine-7(6H)-carboxylate is a high-purity, advanced pharmaceutical intermediate featuring a versatile pyridopyrimidine scaffold. This compound is of significant value for its role as a key building block in the synthesis of complex bioactive molecules, particularly kinase inhibitors. It is primarily needed by research institutions and pharmaceutical companies engaged in the development of novel therapeutics for oncology and other disease areas.

Application

• Pharmaceutical Intermediate: A critical precursor in the multi-step synthesis of targeted small-molecule drugs, especially protein kinase inhibitors.
• Medicinal Chemistry Research: Serves as a versatile scaffold for structure-activity relationship (SAR) studies and the generation of novel compound libraries.
• API Development: Used in the research and process development stages for new active pharmaceutical ingredients (APIs).
• Chemical Biology Probes: Employed in the design and synthesis of chemical probes for studying specific biological pathways and target validation.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations specializing in custom synthesis and scale-up services for the pharmaceutical industry.

Basic Information

Item	Details
Product Name	tert-Butyl 2-(Chloromethyl)-5,8-Dihydropyrido[3,4-d]Pyrimidine-7(6H)-Carboxylate
CAS No.	944906-09-6
Molecular Formula	C14H18ClN3O2
Molecular Weight	295.76 g/mol
Synonyms	tert-Butyl 2-(chloromethyl)-5,8-dihydro-6H-pyrido[3,4-d]pyrimidine-7-carboxylate; 7-(tert-Butoxycarbonyl)-2-(chloromethyl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine; 944906-09-6; BOC-protected chloromethyl pyridopyrimidine; 2-(Chloromethyl)-7-(tert-butoxycarbonyl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine
EINECS	Contact for details

Quality Control

Our tert-Butyl 2-(Chloromethyl)-5,8-dihydropyrido[3,4-d]pyrimidine-7(6H)-carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) with full traceability are provided to support your GMP-compliant development and manufacturing processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.