Description

2-(Chloromethyl)-4-(Trifluoromethyl)Pyrimidine is a high-value, multi-functional heterocyclic building block essential for advanced organic synthesis. This compound matters because its unique structure, featuring both a reactive chloromethyl group and a stable trifluoromethyl substituent, enables the precise construction of complex molecules with tailored properties. It is critically needed by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for creating novel active ingredients and intermediates.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel active pharmaceutical ingredients (APIs), particularly in antiviral, anticancer, and central nervous system (CNS) drug candidates.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the trifluoromethyl group enhances biological activity and metabolic stability.
• Material Science Precursor: Serves as a building block for functionalized polymers, liquid crystals, and organic electronic materials requiring specific pyrimidine-based architectures.
• Cross-Coupling Reactions: The chloromethyl moiety acts as a versatile handle for further functionalization via nucleophilic substitution or metal-catalyzed cross-coupling (e.g., Suzuki, Heck reactions).
• Fluorine Chemistry Research: An important compound for studying the influence of the CF3 group on the reactivity and physicochemical properties of pyrimidine systems.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects requiring specialized fluorinated heterocycles.

Basic Information

Product Name	2-(Chloromethyl)-4-(Trifluoromethyl)Pyrimidine
CAS No.	944905-91-3
Molecular Formula	C6H4ClF3N2
Molecular Weight	196.56 g/mol
Synonyms	4-(Trifluoromethyl)-2-(chloromethyl)pyrimidine; 2-Chloromethyl-4-trifluoromethylpyrimidine; 2-(Chloromethyl)-4-(trifluoromethyl)pyrimidine; Pyrimidine, 2-(chloromethyl)-4-(trifluoromethyl)-; 944905-91-3
EINECS	Contact for details

Quality Control

Our 2-(Chloromethyl)-4-(Trifluoromethyl)Pyrimidine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment supports compliance with cGMP and ICH guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, containers should be kept in opaque packaging or amber glass.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.