Description

5-(Trifluoromethyl)Pyrimidine-2-Carbonitrile is a high-value fluorinated pyrimidine derivative, serving as a critical building block in advanced organic synthesis. Its unique trifluoromethyl-substituted nitrile structure makes it an indispensable intermediate for creating compounds with enhanced metabolic stability and lipophilicity. This product is primarily sought by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for kinase inhibitors and antiviral agents.
• Agrochemical Synthesis: Building block for developing new herbicides and fungicides with improved efficacy and environmental profiles.
• Material Science Research: Used in the development of specialty polymers and liquid crystals due to its fluorine content.
• Chemical Biology: Serves as a versatile scaffold for creating molecular probes and enzyme inhibitors in drug discovery.
• Custom Synthesis: Employed by contract research and manufacturing organizations (CROs/CMOs) for client-specific molecule development.

Basic Information

Product Name	5-(Trifluoromethyl)Pyrimidine-2-Carbonitrile
CAS No.	944905-38-8
Molecular Formula	C6H2F3N3
Molecular Weight	173.10 g/mol
Synonyms	2-Cyano-5-(trifluoromethyl)pyrimidine; 5-(Trifluoromethyl)-2-pyrimidinecarbonitrile; 5-(Trifluoromethyl)pyrimidine-2-carbonitrile; Pyrimidine-2-carbonitrile, 5-(trifluoromethyl)-; 2-Pyrimidinecarbonitrile, 5-(trifluoromethyl)-
EINECS	Contact for details

Quality Control

Our 5-(Trifluoromethyl)Pyrimidine-2-Carbonitrile is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and GC-MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to prevent moisture absorption, which may affect product stability and performance.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.