Description

2-(Piperazin-1-Yl)Pyrimidine-5-Carboxylic Acid is a high-purity heterocyclic building block of significant importance in modern pharmaceutical research and development. This compound serves as a critical intermediate for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring complex molecular architectures. It is primarily sought after by research institutions, custom synthesis houses, and pharmaceutical companies engaged in drug discovery programs for oncology, central nervous system (CNS) disorders, and other specialized treatments.

Application

• Pharmaceutical Intermediate: A key synthon for constructing complex drug molecules, especially kinase inhibitors and other targeted therapies.
• Medicinal Chemistry Research: Used in high-throughput screening and structure-activity relationship (SAR) studies to develop new chemical entities.
• Custom Synthesis: Serves as a starting material or advanced intermediate for contract research organizations (CROs) and CDMOs (Contract Development and Manufacturing Organizations).
• Bioconjugation & Probe Development: The carboxylic acid functional group allows for conjugation to biomolecules, peptides, or fluorescent tags for diagnostic and biochemical research.
• Chemical Library Synthesis: Used to generate diverse compound libraries for biological testing in drug discovery campaigns.
• Agrochemical Research: Potential intermediate in the development of new crop protection agents and herbicides.

Basic Information

Product Name	2-(Piperazin-1-Yl)Pyrimidine-5-Carboxylic Acid
CAS No.	944905-05-9
Molecular Formula	C9H12N4O2
Molecular Weight	208.22 g/mol
Synonyms	2-(1-Piperazinyl)pyrimidine-5-carboxylic acid; 5-Carboxy-2-piperazin-1-ylpyrimidine; 2-Piperazin-1-ylpyrimidine-5-carboxylic acid; Pyrimidine-5-carboxylic acid, 2-(1-piperazinyl)-; 944905-05-9; UNII-9R3J8Q9V5F; 9R3J8Q9V5F
EINECS	Contact for details

Quality Control

Our 2-(Piperazin-1-Yl)Pyrimidine-5-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and tests for residual solvents and heavy metals to ensure it meets the stringent requirements for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) is provided with every shipment, detailing all specifications and test results.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.