Description

4-Methoxy-5H,6H,7H,8H-Pyrido[4,3-D]Pyrimidine CAS NO 944902-70-9 is a high-purity, advanced pharmaceutical intermediate belonging to the pyridopyrimidine class of heterocyclic compounds. This compound is valued for its role as a critical building block in the synthesis of complex active pharmaceutical ingredients (APIs), particularly in oncology and other therapeutic areas. It is primarily sought by research institutions, contract development and manufacturing organizations (CDMOs), and pharmaceutical companies engaged in novel drug discovery and process development.

Application

• Pharmaceutical Intermediate: Serves as a key synthetic precursor in the development of novel small-molecule drug candidates, especially kinase inhibitors.
• Oncology Research: Used in the research and synthesis of targeted cancer therapies due to its pyridopyrimidine scaffold, which is common in many kinase-targeting compounds.
• Chemical Synthesis Building Block: Employed in medicinal chemistry for structure-activity relationship (SAR) studies and lead optimization programs.
• Process Chemistry & Scale-Up: Utilized in the development and optimization of scalable, GMP-compliant synthetic routes for API manufacturing.
• Academic & Industrial R&D: A valuable reagent for researchers in organic chemistry and drug discovery exploring new heterocyclic compounds and their biological activities.

Basic Information

Product Name	4-Methoxy-5H,6H,7H,8H-Pyrido[4,3-D]Pyrimidine
CAS No.	944902-70-9
Molecular Formula	C9H11N3O
Molecular Weight	177.20 g/mol
Synonyms	4-Methoxypyrido[4,3-d]pyrimidine; 4-Methoxy-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine; Pyrido[4,3-d]pyrimidine, 5,6,7,8-tetrahydro-4-methoxy-; 5,6,7,8-Tetrahydro-4-methoxypyrido[4,3-d]pyrimidine
EINECS	Contact for details

Quality Control

Our 4-Methoxy-5H,6H,7H,8H-Pyrido[4,3-D]Pyrimidine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis. We provide Certificates of Analysis (COA) with detailed specifications to ensure traceability and compliance with your research or cGMP guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from incompatible materials. For long-term storage, consider under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.