Description

Ethyl 4-(Chloromethyl)Pyrimidine-2-Carboxylate is a high-value pyrimidine derivative and a versatile synthetic building block in advanced organic chemistry. This compound is critical for the development of novel active pharmaceutical ingredients (APIs) and fine chemicals, offering a reactive chloromethyl handle for further functionalization. It is primarily utilized by research institutions and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of various drug candidates, particularly those targeting central nervous system (CNS) disorders and infectious diseases.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides, leveraging the pyrimidine core's bioactivity.
• Ligand and Catalyst Development: Serves as a starting material for creating specialized ligands and organocatalysts used in asymmetric synthesis.
• Material Science Research: Employed in the development of organic electronic materials and advanced polymers with tailored properties.
• Chemical Biology Probes: Utilized to create molecular probes for studying enzyme function and biological pathways.
• Custom Synthesis and Contract Manufacturing: A critical raw material for CDMOs (Contract Development and Manufacturing Organizations) producing bespoke compounds for client projects.

Basic Information

Product Name	Ethyl 4-(Chloromethyl)Pyrimidine-2-Carboxylate
CAS No.	944902-40-3
Molecular Formula	C8H9ClN2O2
Molecular Weight	200.62 g/mol
Synonyms	Ethyl 4-(chloromethyl)pyrimidine-2-carboxylate; 2-Pyrimidinecarboxylic acid, 4-(chloromethyl)-, ethyl ester; 4-(Chloromethyl)pyrimidine-2-carboxylic acid ethyl ester; Ethyl 4-(chloromethyl)-2-pyrimidinecarboxylate; 944902-40-3; UNII-9J8C9V309U; 9J8C9V309U; SCHEMBL218062; DTXSID60664688
EINECS	Contact for details

Quality Control

Our Ethyl 4-(Chloromethyl)Pyrimidine-2-Carboxylate is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming compliance with agreed specifications. We support cGMP standards for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. The compound may be moisture-sensitive; keep the container tightly sealed under an inert atmosphere if specified.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.