Description

2-Chloro-4-(Chloromethyl)Pyrimidine is a versatile and highly functionalized pyrimidine derivative, serving as a critical building block in advanced organic synthesis. Its value lies in the dual reactivity of the chloro and chloromethyl groups, enabling sequential and selective functionalization to construct complex heterocyclic systems. This compound is essential for research chemists and process development scientists in the pharmaceutical and agrochemical industries, particularly for the development of active pharmaceutical ingredients (APIs) and novel crop protection agents.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of various drug candidates, especially kinase inhibitors and antiviral compounds.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides due to its reactive halogen sites.
• Material Science: Serves as a monomer or cross-linking agent in the creation of specialty polymers and functional materials.
• Chemical Research: A valuable scaffold in medicinal chemistry for structure-activity relationship (SAR) studies and library synthesis.
• Ligand & Catalyst Development: Employed in the preparation of pyrimidine-based ligands for metal complexes used in catalysis.

Basic Information

Product Name	2-Chloro-4-(Chloromethyl)Pyrimidine
CAS No.	944902-31-2
Molecular Formula	C5H4Cl2N2
Molecular Weight	162.99 g/mol
Synonyms	4-(Chloromethyl)-2-chloropyrimidine; 2-Chloro-4-chloromethylpyrimidine; Pyrimidine, 2-chloro-4-(chloromethyl)-; 2,4-Dichloromethylpyrimidine (incorrect but common alias); 4-(Chloromethyl)-2-chloro-1,3-diazine
EINECS	Contact for details

Quality Control

Our 2-Chloro-4-(Chloromethyl)Pyrimidine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing including HPLC, GC, NMR, and mass spectrometry to ensure identity, purity, and consistency. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming compliance with agreed specifications. We support cGMP standards for pharmaceutical applications and can tailor purity grades to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere (e.g., nitrogen) for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.