Description

5-(Chloromethyl)-2-(Trifluoromethyl)Pyrimidine is a high-value, multi-functional heterocyclic building block essential for advanced organic synthesis. Its molecular structure, featuring both a reactive chloromethyl group and a stable trifluoromethyl substituent, makes it a critical intermediate for constructing complex molecules with tailored properties. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in developing antiviral, anticancer, and central nervous system (CNS) drugs.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the trifluoromethyl group enhances biological activity and metabolic stability.
• Material Science: Serves as a precursor for functionalized polymers, liquid crystals, and organic electronic materials requiring specific fluorine-containing motifs.
• Chemical Research & Development: A versatile reagent in medicinal chemistry and process chemistry for introducing the 2-(trifluoromethyl)pyrimidine scaffold into target molecules.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis projects and scale-up production under cGMP or ISO standards.

Basic Information

Product Name	5-(Chloromethyl)-2-(Trifluoromethyl)Pyrimidine
CAS No.	944901-26-2
Molecular Formula	C6H4ClF3N2
Molecular Weight	196.56 g/mol
Synonyms	2-(Trifluoromethyl)-5-(chloromethyl)pyrimidine; 5-(Chloromethyl)-2-(trifluoromethyl)pyrimidine; 2-Trifluoromethyl-5-chloromethylpyrimidine; Pyrimidine, 5-(chloromethyl)-2-(trifluoromethyl)-; 944901-26-2
EINECS	Contact for details

Quality Control

Every batch of 5-(Chloromethyl)-2-(Trifluoromethyl)Pyrimidine is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the precise requirements for research and commercial synthesis. A detailed Certificate of Analysis (COA), including results from HPLC, NMR, and GC-MS, is available for each lot to guarantee identity, purity, and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from strong acids and incompatible organic solvents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.