Description

2,5-Anhydro-1-Azido-1,3-Dideoxy-3-(3,4-Dihydro-5-Methyl-2,4-Dioxo-1(2H)-Pyrimidinyl)-L-Mannitol is a sophisticated nucleoside analogue building block of significant interest in advanced pharmaceutical research and development. Its unique structure, incorporating a modified mannitol backbone linked to a dihydropyrimidinone moiety, makes it a critical intermediate for the synthesis of novel antiviral and anticancer agents. This high-purity compound is essential for medicinal chemistry programs targeting nucleoside metabolism, particularly within global R&D centers focused on next-generation therapeutics.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel nucleoside-based antiviral and anticancer drug candidates.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies to optimize potency and selectivity of therapeutic molecules.
• Biochemical Probe Development: Serves as a precursor for labeled compounds used in enzyme inhibition and metabolic pathway studies.
• Process Chemistry & Scale-Up: Employed in the development and optimization of scalable synthetic routes for active pharmaceutical ingredients (APIs).
• Academic & Institutional Research: Utilized in universities and research institutes for exploring new mechanisms in nucleoside chemistry and drug design.
• Contract Research & Manufacturing (CRO/CMO): Supplied to service organizations supporting pharmaceutical companies with custom synthesis and development.

Basic Information

Product Name	2,5-Anhydro-1-Azido-1,3-Dideoxy-3-(3,4-Dihydro-5-Methyl-2,4-Dioxo-1(2H)-Pyrimidinyl)-L-Mannitol
CAS No.	944475-10-9
Molecular Formula	C11H14N6O6
Molecular Weight	326.27 g/mol
Synonyms	1-Azido-2,5-anhydro-1,3-dideoxy-3-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-L-mannitol; 3-(3,4-Dihydro-5-methyl-2,4-dioxo-1(2H)-pyrimidinyl)-2,5-anhydro-1-azido-1,3-dideoxy-L-mannitol; L-Mannitol, 2,5-anhydro-1-azido-1,3-dideoxy-3-(3,4-dihydro-5-methyl-2,4-dioxo-1(2H)-pyrimidinyl)-; Nucleoside Mannitol Derivative; Azido Dideoxy Mannitol Pyrimidinone; CAS 944475-10-9
EINECS	Contact for details

Quality Control

Every batch of this advanced intermediate is produced and analyzed under strict quality management systems. We provide comprehensive Certificates of Analysis (COA) detailing purity, identity, and impurity profiles to ensure it meets the exacting standards required for pharmaceutical R&D. Our commitment to cGMP principles and analytical rigor guarantees batch-to-batch consistency and traceability for your critical development projects.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at a controlled room temperature (15-25°C) in a dry, well-ventilated area. Due to its sensitivity, the container should be kept sealed and allowed to reach ambient temperature before opening to minimize moisture ingress and oxidative degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.