Description

4-(4,6-Dichloro-5-Fluoropyrimidin-2-Yl)Morpholine is a high-purity fluorinated pyrimidine derivative, a crucial building block in modern pharmaceutical and agrochemical synthesis. Its value lies in its role as a key intermediate for creating active molecules with enhanced biological activity and selectivity. This compound is essential for R&D chemists and process development scientists in the pharmaceutical, crop protection, and advanced materials sectors seeking to develop new active ingredients.

Application

• Pharmaceutical Intermediate: A critical synthon for the development of novel kinase inhibitors, antiviral agents, and other small-molecule therapeutics.
• Agrochemical Synthesis: Used in the research and production of next-generation herbicides, fungicides, and insecticides that leverage the fluoropyrimidine scaffold.
• Chemical Research & Development: Serves as a versatile precursor for exploring new chemical entities and conducting structure-activity relationship (SAR) studies.
• Process Chemistry & Scale-Up: Employed in the optimization and commercial-scale manufacturing of active pharmaceutical ingredients (APIs) and agrochemicals.
• Custom Synthesis & Contract Manufacturing: A key starting material for specialty chemical manufacturers offering bespoke synthesis services.

Basic Information

Product Name	4-(4,6-Dichloro-5-Fluoropyrimidin-2-Yl)Morpholine
CAS No.	944401-90-5
Molecular Formula	C8H8Cl2FN3O
Molecular Weight	252.07 g/mol
Synonyms	2-(4,6-Dichloro-5-fluoropyrimidin-2-yl)morpholine; 4,6-Dichloro-5-fluoro-2-morpholinopyrimidine; 5-Fluoro-4,6-dichloro-2-morpholinopyrimidine; Morpholine, 4-(4,6-dichloro-5-fluoropyrimidin-2-yl)-; 944401-90-5; CAS 944401-90-5
EINECS	Contact for details

Quality Control

Every batch of 4-(4,6-Dichloro-5-Fluoropyrimidin-2-Yl)Morpholine is manufactured and tested under strict quality management systems. We ensure compliance with relevant industry standards for fine chemical intermediates. Comprehensive analytical testing, including HPLC, GC, NMR, and MS, is performed to verify identity, purity, and impurity profiles. A Certificate of Analysis (COA) documenting all test results is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to minimize exposure to atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC/IR)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.