Description

(tert-Butoxy)Carbonyl Thr((9H-Fluoren-9-Yl)Methoxy]Carbonyl Asp(Otbu))-Oh is a sophisticated, orthogonally protected dipeptide building block designed for advanced peptide synthesis. This compound is critical for researchers and manufacturers requiring high-purity intermediates to construct complex peptide sequences with precise control over side-chain reactivity. It is primarily utilized in pharmaceutical R&D and process development for novel therapeutic peptides, including those targeting metabolic and oncological pathways.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected intermediate for the sequential assembly of peptide chains on resin, particularly in Fmoc/t-Bu chemistry.
• Solution-Phase Peptide Synthesis: Used in fragment condensation strategies to build longer or more complex peptide sequences.
• Pharmaceutical Research: Serves as a crucial building block in the development of peptide-based drug candidates, including hormone analogs and enzyme inhibitors.
• Process Chemistry & Scale-Up: Employed in the development and optimization of manufacturing routes for therapeutic peptides under GMP conditions.
• Bioconjugation & Peptide Labeling: The reactive, protected functional groups allow for selective deprotection and subsequent conjugation with labels, tags, or other biomolecules.
• Academic & Institutional Research: A valuable reagent for studying peptide structure-activity relationships (SAR) and developing new synthetic methodologies.

Basic Information

Product Name	(tert-Butoxy)Carbonyl Thr((9H-Fluoren-9-Yl)Methoxy]Carbonyl Asp(Otbu))-Oh
CAS No.	944283-33-4
Molecular Formula	C33H42N2O9
Molecular Weight	610.70 g/mol
Synonyms	Boc-Thr(Fmoc-Asp(OtBu))-OH; Boc-L-Threonyl-N-α-(9-fluorenylmethoxycarbonyl)-L-aspartic acid 4-tert-butyl ester; Fmoc-Asp(OtBu)-Thr(Boc)-OH; Boc-Thr(Fmoc-Asp(OtBu))-OH; N-α-Boc-O-Fmoc-L-threonyl-L-aspartic acid 4-tert-butyl ester; Protected Thr-Asp dipeptide; Boc-Thr(Fmoc-Asp(OtBu))-OH dipeptide building block
EINECS	Contact for details

Quality Control

Our (tert-Butoxy)Carbonyl Thr((9H-Fluoren-9-Yl)Methoxy]Carbonyl Asp(Otbu))-Oh is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity suitable for sensitive research and development applications. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles, typically determined by HPLC, NMR, and mass spectrometry. We adhere to relevant industry standards for fine chemical and pharmaceutical intermediate production.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as specified on the label or COA. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Allow the container to reach room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Assay	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.