Description

(tert-Butoxy)Carbonyl Thr((9H-Fluoren-9-Yl)Methoxy]Carbonyl Ser(Tbu))-Oh is a sophisticated, multi-protected peptide derivative designed for advanced solid-phase peptide synthesis (SPPS). This compound matters as a critical building block for the controlled assembly of complex peptides and proteins, offering orthogonal protection for serine and threonine side chains. It is essential for researchers and manufacturers in pharmaceutical development, particularly for creating therapeutic peptides, vaccines, and biochemical probes where precise sequence control is paramount.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected amino acid derivative for the sequential construction of custom peptide sequences.
• Pharmaceutical Intermediate: Used in the research and development of novel peptide-based therapeutics, including hormone analogs and enzyme inhibitors.
• Bioconjugation: Serves as a precursor for creating peptide-drug conjugates or peptide-labeled biomolecules.
• Combinatorial Chemistry: Employed in libraries for high-throughput screening to discover new bioactive compounds.
• Academic & Industrial Research: A vital reagent for studying protein structure-function relationships and post-translational modifications.
• Production of Protected Peptide Fragments: For use in fragment condensation or native chemical ligation strategies.

Basic Information

Product Name	(tert-Butoxy)Carbonyl Thr((9H-Fluoren-9-Yl)Methoxy]Carbonyl Ser(Tbu))-Oh
CAS No.	944283-28-7
Molecular Formula	C33H42N2O9
Molecular Weight	610.70 g/mol
Synonyms	Fmoc-Ser(tBu)-Thr(Boc)-OH; Boc-Thr(Fmoc-Ser(O-tBu))-OH; N-α-Boc-O-Fmoc-L-threonyl-O-tert-butyl-L-serine; Fmoc-Ser(tBu)-Thr(Boc)-OH peptide building block; (2S,3R)-2-[(2S)-2-[(tert-Butoxy)carbonylamino]-3-hydroxybutanamido]-3-[(9H-fluoren-9-ylmethoxy)carbonylamino]-3-[(2-methylpropan-2-yl)oxy]propanoic acid; Protected L-Threonyl-L-Serine derivative; Boc-Thr(Fmoc-Ser(OtBu))-OH
EINECS	Contact for details

Quality Control

Our (tert-Butoxy)Carbonyl Thr((9H-Fluoren-9-Yl)Methoxy]Carbonyl Ser(Tbu))-Oh is manufactured under strict quality systems suitable for research and pharmaceutical applications. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral integrity, to ensure compliance with exacting standards. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee batch-to-batch consistency and traceability.

Storage

Preserve in a tightly closed container, protected from light. Store in a freezer at -20°C to -15°C. This product is hygroscopic (moisture-sensitive). Allow the sealed container to reach room temperature before opening to prevent condensation and moisture ingress. For long-term storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 97.0%
Optical Rotation	Contact for details
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residual Solvents	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.