Description

Boc-Thr(Ile-Fmoc)-Oh is a specialized, high-purity protected amino acid derivative essential for solid-phase peptide synthesis (SPPS). This compound matters because it provides orthogonal protection for the threonine and isoleucine side chains, enabling the precise, sequential construction of complex peptides and proteins. It is critically needed by pharmaceutical R&D teams, biotechnology companies, and CROs engaged in the development of therapeutic peptides, peptide hormones, and research biochemicals.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key building block for the automated, sequential assembly of peptide chains, particularly in Fmoc-based synthesis strategies.
• Pharmaceutical Research & Development: Used in the discovery and development of novel peptide-based therapeutics, including anticancer agents, antimicrobial peptides, and metabolic regulators.
• Bioconjugation and Peptide Labeling: Serves as a precursor for creating custom peptides with specific tags or functional groups for diagnostic or targeting applications.
• Academic and Industrial Biochemistry: Essential for studying protein structure-function relationships, enzyme-substrate interactions, and signal transduction pathways.
• Production of Custom Peptides: Used by CROs and CDMOs for the contract manufacturing of research-grade and GMP-grade peptides for clinical trials.
• Combinatorial Chemistry Libraries: A valuable component for generating diverse peptide libraries used in high-throughput screening for drug discovery.

Basic Information

Product Name	Boc-Thr(Ile-Fmoc)-Oh
CAS No.	944283-27-6
Molecular Formula	C₃₃H₄₄N₂O₈
Molecular Weight	608.72 g/mol
Synonyms	N-α-Boc-O-(N-ε-Fmoc-L-isoleucyl)-L-threonine; Boc-Thr(Ile-Fmoc)-OH; Boc-L-Thr[L-Ile(Fmoc)]-OH; (2S,3R)-2-[(tert-Butoxycarbonyl)amino]-3-[(2S,3S)-2-[(9H-fluoren-9-ylmethoxy)carbonyl]amino]-3-methylpentanoyl]oxy]butanoic acid; Fmoc-Ile-Thr(Boc)-OH; Protected Threonine-Isoleucine Dipeptide; Boc-Thr(Fmoc-Ile)-OH
EINECS	Contact for details

Quality Control

Our Boc-Thr(Ile-Fmoc)-Oh is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity, typically meeting standards suitable for advanced peptide synthesis. Every lot is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We ensure compliance with relevant industry guidelines for research chemicals and can provide material traceability documentation upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a freezer at -20°C to -15°C. This material is hygroscopic (moisture-sensitive) and should be allowed to equilibrate to room temperature in a dry environment before opening to prevent condensation and hydrolysis. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms to reference spectrum
Assay (HPLC)	≥97.0%
Specific Rotation	Contact for details
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.