Description

Boc-Thr(Leu-Fmoc)-OH is a protected dipeptide building block of significant importance in solid-phase peptide synthesis (SPPS). This compound is specifically designed to facilitate the controlled, sequential assembly of complex peptides by providing orthogonal protection for the amino and carboxyl termini. It is a critical raw material for research institutions and pharmaceutical companies engaged in the development of therapeutic peptides, peptide hormones, and biochemical probes. The product, identified by CAS number 944283-26-5, offers high purity and reliability for demanding synthetic applications.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a key intermediate for the Fmoc/t-Bu strategy, enabling the precise construction of peptide chains.
• Pharmaceutical Research & Development: Used in the discovery and synthesis of novel peptide-based drug candidates and active pharmaceutical ingredients (APIs).
• Bioconjugation: Serves as a component for creating peptide-protein or peptide-small molecule conjugates for targeted therapies.
• Combinatorial Chemistry: Employed in libraries for high-throughput screening to identify bioactive peptide sequences.
• Biochemical Tool Development: Integral for synthesizing labeled peptides, enzyme substrates, or inhibitors for proteomics and diagnostic research.
• Academic Research: A fundamental reagent in university and institutional labs studying protein structure, function, and peptide chemistry.

Basic Information

Product Name	Boc-Thr(Leu-Fmoc)-OH
CAS No.	944283-26-5
Molecular Formula	C30H38N2O8
Molecular Weight	554.64 g/mol
Synonyms	Boc-Thr(Leu-Fmoc)-OH; N-α-(tert-Butoxycarbonyl)-O-(9-fluorenylmethyloxycarbonyl)-L-threonyl-L-leucine; Boc-L-Thr(Fmoc-L-Leu)-OH; (2S,3R)-3-[[(2S)-2-[[(2-methylpropan-2-yl)oxycarbonyl]amino]-3-methylbutanoyl]oxy]-2-[(9H-fluoren-9-ylmethoxycarbonyl)amino]butanoic acid; tert-Butyloxycarbonyl-L-threonyl-N-α-(9-fluorenylmethoxycarbonyl)-L-leucine; Fmoc-Leu-Thr(Boc)-OH (reverse sequence notation); Boc-Thr(Fmoc-Leu)-OH; Protected Thr-Leu dipeptide
EINECS	Contact for details

Quality Control

Our Boc-Thr(Leu-Fmoc)-OH is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research and pharmaceutical applications. Each lot undergoes rigorous analytical testing, including HPLC for purity, chiral analysis for enantiomeric excess, and spectroscopic methods for structural confirmation. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Specific Rotation	Contact for details
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.