Description

Boc-Thr(Fmoc-Gly)-Oh is a protected dipeptide building block of significant importance in solid-phase peptide synthesis (SPPS). This compound is specifically designed to facilitate the controlled and sequential assembly of complex peptide chains, offering orthogonal protection for the threonine side chain and the N-terminus. It is a critical raw material for researchers and manufacturers in the pharmaceutical and biotechnology sectors developing therapeutic peptides, diagnostic agents, and biochemical tools. The high purity and reliable performance of this building block are essential for ensuring the success and reproducibility of sophisticated peptide synthesis projects.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key intermediate for the Fmoc/t-Bu strategy, enabling the controlled incorporation of a threonine-glycine sequence into target peptides.
• Pharmaceutical Research & Development: Used in the discovery and development of novel peptide-based therapeutics, including hormones, antibiotics, and enzyme inhibitors.
• Bioconjugation & Labeling: Serves as a precursor for creating peptide conjugates with drugs, reporter molecules, or polymers for targeted delivery and imaging.
• Combinatorial Chemistry Libraries: Employed in the generation of diverse peptide libraries for high-throughput screening against biological targets.
• Biochemical Reagent Production: Used in the custom synthesis of substrates, inhibitors, or standards for enzymatic assays and analytical methods.
• Academic & Institutional Research: A fundamental reagent for studies in peptide chemistry, structural biology, and medicinal chemistry within university and government laboratories.

Basic Information

Item	Details
Product Name	Boc-Thr(Fmoc-Gly)-Oh
CAS No.	944283-25-4
Molecular Formula	C26H30N2O8
Molecular Weight	498.53 g/mol
Synonyms	Boc-Thr(Fmoc-Gly)-OH; N-[(1,1-Dimethylethoxy)carbonyl]-O-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-threonylglycine; Boc-L-Thr(Fmoc-Gly)-OH; Boc-Threonine(Fmoc-Glycine)-OH; tert-Butyloxycarbonyl-O-(9-fluorenylmethyloxycarbonyl)threonylglycine; Fmoc-Gly-Thr(Boc)-OH (sequence variant); Protected Thr-Gly dipeptide; SPPS Building Block for Thr-Gly
EINECS	Contact for details

Quality Control

Every batch of Boc-Thr(Fmoc-Gly)-Oh is manufactured and tested under a strict quality management system to ensure it meets the exacting standards required for advanced peptide synthesis. Our quality control protocols include comprehensive analytical characterization using HPLC, NMR, and mass spectrometry to verify identity, purity, and chiral integrity. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting critical parameters such as assay purity, enantiomeric excess, and residual solvent levels. We are committed to supplying material that supports your cGMP and non-GMP research and development needs with reliable consistency.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This product is hygroscopic (moisture-sensitive). Allow the sealed container to equilibrate to room temperature before opening to prevent condensation and moisture uptake. For long-term storage, consider storing under an inert atmosphere such as argon or nitrogen.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Specific Rotation	Contact for details
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.