Description

Boc-Ser(Fmoc-Phe)-Oh is a specialized, orthogonally protected dipeptide building block used in solid-phase peptide synthesis (SPPS). This compound is critical for enabling complex, multi-step peptide assembly by providing selective deprotection points for the serine and phenylalanine side chains. It is primarily utilized by research institutions, pharmaceutical R&D departments, and fine chemical manufacturers engaged in the development of therapeutic peptides, peptide hormones, and biochemical tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key intermediate for the controlled, sequential assembly of longer peptide sequences in automated synthesizers.
• Pharmaceutical Research: Building block for the discovery and development of novel peptide-based drugs and active pharmaceutical ingredients (APIs).
• Bioconjugation: Used to introduce specific amino acid sequences with orthogonal protecting groups for subsequent labeling or coupling reactions.
• Combinatorial Chemistry: Essential component in libraries for screening biological activity and structure-activity relationship (SAR) studies.
• Academic & Biochemical Research: Synthesis of custom peptides for studying protein-protein interactions, enzyme substrates, and receptor ligands.
• Process Development: Serves as a reference standard or starting material for scaling up GMP-grade peptide manufacturing processes.

Basic Information

Product Name	Boc-Ser(Fmoc-Phe)-Oh
CAS No.	944283-23-2
Molecular Formula	C32H34N2O8
Molecular Weight	574.62 g/mol
Synonyms	Boc-Ser(Fmoc-Phe)-OH; N-α-Boc-O-(N-α-Fmoc-L-phenylalanyl)-L-serine; tert-Butyloxycarbonyl-O-[N-(9-fluorenylmethoxycarbonyl)-L-phenylalanyl]-L-serine; Boc-L-Ser(Fmoc-L-Phe)-OH; Boc-Ser(Fmoc-Phe)-OH dipeptide; Fmoc-Phe-Ser(Boc)-OH (reverse sequence notation); (2S)-2-[(2-{[(9H-fluoren-9-ylmethoxy)carbonyl]amino}-3-phenylpropanoyl)oxy]-3-[(2-methylpropan-2-yl)oxycarbonylamino]propanoic acid
EINECS	Contact for details

Quality Control

Our Boc-Ser(Fmoc-Phe)-Oh is manufactured under strict quality systems to ensure high purity and batch-to-batch consistency, suitable for sensitive research and development applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry guidelines to support our customers' quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions at -20°C.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Assay (HPLC)	≥ 98.0%
Specific Rotation	Contact for details
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.