Description

Boc-Ser(Fmoc-Gln(Trt))-OH is a protected amino acid derivative, specifically a building block for solid-phase peptide synthesis (SPPS). This compound is essential for the controlled and sequential assembly of complex peptides, ensuring high coupling efficiency and purity. It is primarily used by research institutions, pharmaceutical R&D departments, and fine chemical manufacturers developing therapeutic peptides, peptide hormones, and biochemical tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key intermediate for the Fmoc/t-Bu strategy, enabling the incorporation of serine and glutamine residues into peptide chains.
• Pharmaceutical Research & Development: Used in the synthesis of novel peptide-based drug candidates, including anticancer, antimicrobial, and metabolic disorder therapeutics.
• Bioconjugation and Labeling: Serves as a precursor for creating custom peptides with specific tags or functional groups for diagnostic and imaging applications.
• Combinatorial Chemistry Libraries: Employed in the generation of diverse peptide libraries for high-throughput screening and drug discovery.
• Academic & Biochemical Research: Utilized in studies of protein-protein interactions, enzyme substrates, and receptor ligands.
• Custom Peptide Service Providers: A critical raw material for companies offering bespoke peptide synthesis services to the research community.

Basic Information

Product Name	Boc-Ser(Fmoc-Gln(Trt))-OH
CAS No.	944283-19-6
Molecular Formula	C46H47N3O8
Molecular Weight	769.89 g/mol
Synonyms	N-α-Boc-O-(N-α-Fmoc-N-γ-trityl-L-glutaminyl)-L-serine; Boc-Ser(Fmoc-Gln(Trt))-OH; Boc-L-Ser(Fmoc-L-Gln(Trt))-OH; (S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)(1-((tert-butoxycarbonyl)amino)-2-hydroxyethyl)amino)-5-oxo-5-(tritylamino)pentanoic acid; Fmoc-Gln(Trt)-Ser(Boc)-OH (reverse notation); Boc-Ser(Fmoc-Gln(Trt))-OH CAS 944283-19-6; Protected Ser-Gln dipeptide derivative; SPPS Building Block for Serine and Glutamine.
EINECS	Contact for details

Quality Control

Our Boc-Ser(Fmoc-Gln(Trt))-OH is manufactured under strict quality control protocols to ensure consistency and high purity suitable for sensitive peptide synthesis. Each batch is tested to meet stringent specifications, with a focus on chiral purity and low levels of deletion sequences. Certificates of Analysis (COA) detailing identity, purity (HPLC), and specific rotation are available upon request, supporting compliance with cGMP guidelines for pharmaceutical research applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This product is hygroscopic (moisture-sensitive). Allow the sealed container to equilibrate to room temperature before opening to minimize moisture absorption. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Specific Rotation	-15.0° to -20.0° (c=1, DMF)
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.