Description

(tert-Butoxy)Carbonyl Ser((9H-Fluoren-9-Yl)Methoxy]Carbonyl Thr(Tbu))-Oh is a specialized, high-purity protected amino acid derivative designed for advanced peptide synthesis. This compound matters for its critical role in solid-phase peptide synthesis (SPPS), where it provides orthogonal protection for serine and threonine side chains, enabling the construction of complex peptide sequences with high fidelity. Pharmaceutical researchers and fine chemical manufacturers need this building block for the development of therapeutic peptides, diagnostic agents, and biochemical tools.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel therapeutic peptides and peptidomimetics for drug discovery and development.
• Solid-Phase Peptide Synthesis (SPPS): Used in Fmoc/tBu-based strategies for the controlled incorporation of Serine (Ser) and Threonine (Thr) residues with protected side chains.
• Bioconjugation & Labeling: Serves as a precursor for creating custom peptides used in antibody-drug conjugates (ADCs) or diagnostic probes.
• Research & Development: Essential for academic and industrial R&D in biochemistry, medicinal chemistry, and chemical biology for studying protein structure and function.
• Custom Peptide Manufacturing: Employed by CDMOs (Contract Development and Manufacturing Organizations) for the GMP and non-GMP production of complex peptide APIs.
• Combinatorial Chemistry: Utilized in the generation of peptide libraries for high-throughput screening against biological targets.

Basic Information

Product Name	(tert-Butoxy)Carbonyl Ser((9H-Fluoren-9-Yl)Methoxy]Carbonyl Thr(Tbu))-Oh
CAS No.	944283-12-9
Molecular Formula	C33H42N2O9
Molecular Weight	610.70 g/mol
Synonyms	Fmoc-Ser(tBu)-Thr(tBu)-OH; Boc-Ser(tBu)-Thr(tBu)-OH (deprotected N-terminus variant); N-α-Boc-O-tert-butyl-L-seryl-O-tert-butyl-L-threonine; N-Boc-L-Ser(tBu)-L-Thr(tBu)-OH; Protected Serine-Threonine Dipeptide; Boc-Ser(But)-Thr(But)-OH; Fmoc-Ser(O-tBu)-Thr(O-tBu)-OH; (2S,3S)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-3-((tert-butoxy)carbonyl)oxy)butanoic acid (related structure)
EINECS	Contact for details

Quality Control

Our (tert-Butoxy)Carbonyl Ser((9H-Fluoren-9-Yl)Methoxy]Carbonyl Thr(Tbu))-Oh is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for pharmaceutical research and peptide synthesis. Certificates of Analysis (COA) detailing purity, chiral integrity, and impurity profiles are provided with every shipment. We support compliance with relevant guidelines for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This product is hygroscopic (moisture-sensitive) and light-sensitive. Allow the sealed container to equilibrate to room temperature before opening to prevent condensation and moisture ingress. For long-term storage, consider storage under an inert atmosphere such as argon or nitrogen.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Specific Rotation	Contact for details
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.