Description

6-Bromo-7-Methyl-8-Nitroquinazolin-4(3H)-One is a high-purity, advanced pharmaceutical intermediate belonging to the quinazolinone class of heterocyclic compounds. This compound matters as a critical building block in the synthesis of targeted small-molecule drugs, particularly kinase inhibitors used in oncology research. Pharmaceutical R&D teams and fine chemical manufacturers need this precisely functionalized intermediate to develop new therapeutic agents and conduct structure-activity relationship (SAR) studies.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of novel kinase inhibitors and other targeted cancer therapies.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to explore new bioactive molecules.
• Biochemical Tool Compound: Employed in biochemical assays to study enzyme inhibition mechanisms and cellular signaling pathways.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations specializing in custom synthesis and process development for clinical candidates.
• Academic Research: Utilized in university and institutional labs for heterocyclic chemistry and drug discovery projects.

Basic Information

Product Name	6-Bromo-7-Methyl-8-Nitroquinazolin-4(3H)-One
CAS No.	943605-86-5
Molecular Formula	C9H6BrN3O3
Molecular Weight	284.07 g/mol
Synonyms	6-Bromo-7-methyl-8-nitro-3,4-dihydroquinazolin-4-one; 8-Nitro-6-bromo-7-methyl-4(3H)-quinazolinone; 4(3H)-Quinazolinone, 6-bromo-7-methyl-8-nitro-; 6-Bromo-7-methyl-8-nitroquinazolin-4-ol; 943605-86-5; 6-Br-7-Me-8-NO2-quinazolin-4-one
EINECS	Contact for details

Quality Control

Our 6-Bromo-7-Methyl-8-Nitroquinazolin-4(3H)-One is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the high standards required for pharmaceutical research. Certificates of Analysis (COA) with detailed chromatographic data are available upon request to support your regulatory and R&D documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Keep the container sealed to protect this light-sensitive material from moisture and degradation.

Specification

Item	Specification
Appearance	Yellow to light brown crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.