Description

tert-Butyl 4-Chloro-1H-pyrazolo[3,4-d]pyrimidine-1-carboxylate is a high-purity, protected heterocyclic building block of significant importance in modern pharmaceutical research and development. This compound serves as a versatile and critical intermediate for the synthesis of novel kinase inhibitors and other biologically active molecules. It is primarily utilized by research institutions, pharmaceutical companies, and fine chemical manufacturers engaged in the development of targeted cancer therapies and other small-molecule drugs.

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the development of protein kinase inhibitors, particularly for oncology targets.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization for novel drug candidates.
• Chemical Biology Probes: Serves as a scaffold for creating tool compounds to study specific biological pathways and enzyme functions.
• Custom Synthesis: Employed by fine chemical suppliers for the contract manufacturing of advanced pharmaceutical intermediates (APIs).
• Library Synthesis: A valuable building block for generating diverse compound libraries for high-throughput screening in drug discovery.

Basic Information

Product Name	tert-Butyl 4-Chloro-1H-pyrazolo[3,4-d]pyrimidine-1-carboxylate
CAS No.	943324-22-9
Molecular Formula	C10H11ClN4O2
Molecular Weight	254.67 g/mol
Synonyms	1-Boc-4-chloro-1H-pyrazolo[3,4-d]pyrimidine; 4-Chloro-1H-pyrazolo[3,4-d]pyrimidine-1-carboxylic acid tert-butyl ester; 4-Chloro-1-(tert-butoxycarbonyl)-1H-pyrazolo[3,4-d]pyrimidine; tert-Butyl 4-chloro-1H-pyrazolo[3,4-d]pyrimidine-1-carboxylate; 1H-Pyrazolo[3,4-d]pyrimidine-1-carboxylic acid, 4-chloro-, 1,1-dimethylethyl ester; 943324-22-9; Boc-4-chloro-1H-pyrazolo[3,4-d]pyrimidine
EINECS	Contact for details

Quality Control

Our tert-Butyl 4-Chloro-1H-pyrazolo[3,4-d]pyrimidine-1-carboxylate is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the high standards required for pharmaceutical R&D. A detailed Certificate of Analysis (COA) is provided with each shipment, guaranteeing traceability, consistency, and compliance with your specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from heat and incompatible materials. For long-term storage, consider storing under an inert atmosphere to ensure maximum stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Impurity (HPLC)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.