Description

4-n-(Cyclopropylmethyl)-6-[(3R)-3-(Methylamino)Pyrrolidin-1-Yl]Pyrimidine-2,4-Diamine is a high-purity, advanced pharmaceutical intermediate with a complex heterocyclic structure. This compound is of significant value in medicinal chemistry research and development, particularly for its role as a key building block in the synthesis of targeted therapeutic agents. It is primarily required by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in the development of novel drug candidates, especially within oncology and central nervous system (CNS) therapeutic areas.

Application

• Pharmaceutical Intermediate: A critical precursor in the multi-step synthesis of novel active pharmaceutical ingredients (APIs) for clinical research.
• Medicinal Chemistry Research: Used as a core scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Kinase Inhibitor Development: Serves as a key structural component in the design and synthesis of potential kinase inhibitor candidates.
• Process Chemistry & Scale-up: Employed in route scouting and process development for the commercial-scale manufacturing of investigational drugs.
• Reference Standard: Can be utilized as a high-purity analytical standard for quality control and method development in analytical laboratories.
• Contract Research & Manufacturing (CRAM): Supplied to organizations specializing in custom synthesis and development services for the biopharma industry.

Basic Information

Product Name	4-n-(Cyclopropylmethyl)-6-[(3R)-3-(Methylamino)Pyrrolidin-1-Yl]Pyrimidine-2,4-Diamine
CAS No.	943057-12-3
Molecular Formula	C13H23N7
Molecular Weight	277.37 g/mol
Synonyms	4-(Cyclopropylmethyl)-6-[(3R)-3-(methylamino)-1-pyrrolidinyl]-2,4-pyrimidinediamine; 6-[(3R)-3-(Methylamino)pyrrolidin-1-yl]-4-(cyclopropylmethyl)pyrimidine-2,4-diamine; (R)-4-(Cyclopropylmethyl)-6-(3-(methylamino)pyrrolidin-1-yl)pyrimidine-2,4-diamine; 943057-12-3; UNII-9K2Y3W3X4I; 9K2Y3W3X4I
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems, ensuring batch-to-batch consistency and high purity. Each lot is fully characterized and undergoes rigorous analytical testing, including HPLC for purity and chiral purity, to meet the exacting standards of pharmaceutical development. A comprehensive Certificate of Analysis (COA) detailing identity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic nature, the container should be kept in a dry environment and opened under conditions of low humidity to prevent moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.