Description

L-Homopropargylglycine (Hpg) is a non-canonical amino acid analog featuring a propargyl side chain, making it a valuable bioorthogonal chemical reporter. Its primary significance lies in its ability to be incorporated into newly synthesized proteins in place of methionine, enabling selective labeling and detection via click chemistry. This compound is essential for researchers and developers in pharmaceutical R&D, proteomics, and chemical biology who require tools for studying protein synthesis, localization, and turnover in living systems.

Application

• Bioorthogonal Labeling in Proteomics: Used as a metabolic label for nascent protein synthesis, enabling visualization and purification via copper-catalyzed azide-alkyne cycloaddition (CuAAC) or strain-promoted click reactions.
• Chemical Biology Research: Serves as a critical tool for investigating dynamic biological processes, including protein trafficking, degradation, and post-translational modifications in live cells.
• Drug Discovery Platforms: Employed in target identification and validation studies to label and track specific proteins of interest in complex biological matrices.
• Antibody-Drug Conjugate (ADC) Development: Facilitates site-specific conjugation strategies by providing a unique chemical handle for linking payloads to antibodies or other biologics.
• Virology and Microbiology Studies: Applied to monitor pathogen-specific protein synthesis during infection, aiding in the understanding of host-pathogen interactions.
• Neuroscience Research: Utilized for mapping activity-dependent protein synthesis in neurons to study synaptic plasticity, learning, and memory.

Basic Information

Item	Details
Product Name	L-Homopropargylglycine (Hpg)
CAS No.	942518-19-6
Molecular Formula	C6H9NO2
Molecular Weight	127.14 g/mol
Synonyms	L-2-Amino-5-hexynoic acid; HPG; Homopropargylglycine; (S)-2-Amino-5-hexynoic acid; L-α-Amino-γ-butynoic acid; Click chemistry amino acid; Met analog; Azidohomoalanine analog; AHA analog
EINECS	Contact for details

Quality Control

Our L-Homopropargylglycine is manufactured under strict quality systems to ensure high purity and batch-to-batch consistency suitable for sensitive research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to ISO 9001 quality management principles, and our analytical methods, including HPLC and NMR, are validated to provide reliable specifications for the scientific community.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation from atmospheric moisture. For long-term storage, consider desiccant or inert atmosphere conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Optical Rotation [α]20/D	Contact for details
Water Content (KF)	≤ 1.0%
Heavy Metals (as Pb)	≤ 10 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.