Description

4-Chloroquinazoline-7-Carboxylic Acid is a high-purity, synthetically valuable heterocyclic building block. This compound is essential for medicinal chemistry research and the development of novel active pharmaceutical ingredients (APIs), particularly as a key intermediate in kinase inhibitor synthesis. It is primarily utilized by pharmaceutical R&D laboratories, fine chemical manufacturers, and CROs/CMOs engaged in targeted drug discovery programs.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of tyrosine kinase inhibitors and other small-molecule therapeutics.
• Medicinal Chemistry Research: Serves as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery.
• Chemical Biology Probes: Used to develop tool compounds for studying cellular signaling pathways and target validation.
• Custom Synthesis: Employed in contract research and manufacturing for producing bespoke molecules and advanced intermediates.
• Academic Research: Utilized in university and institutional labs for heterocyclic chemistry and synthetic methodology development.

Basic Information

Product Name	4-Chloroquinazoline-7-Carboxylic Acid
CAS No.	942507-89-3
Molecular Formula	C9H5ClN2O2
Molecular Weight	208.60 g/mol
Synonyms	7-Quinazolinecarboxylic acid, 4-chloro-; 4-Chloro-7-quinazolinecarboxylic acid; 4-Chloroquinazoline-7-carboxylic acid; 942507-89-3; 4-Chloro-quinazoline-7-carboxylic acid; 4-Chloro-7-carboxyquinazoline; 7-Carboxy-4-chloroquinazoline
EINECS	Contact for details

Quality Control

Our 4-Chloroquinazoline-7-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (NMR, IR, MS), to ensure it meets the stringent requirements for pharmaceutical R&D. A detailed Certificate of Analysis (COA) is provided with every shipment, guaranteeing traceability and compliance with your specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at controlled room temperature (15-25°C). The compound may be moisture-sensitive; keep the container tightly sealed in a dry environment.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms to reference spectrum
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.