Description

Pentafluorophenyl 1-Methyl-1H-Indole-7-Carboxylate is a specialized fluorinated indole derivative, serving as a high-value synthetic intermediate in advanced organic chemistry. This compound is particularly significant for its role in constructing complex molecules, where the pentafluorophenyl ester group acts as a versatile and reactive handle for amide bond formation and other coupling reactions. It is primarily needed by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs), agrochemicals, and functional materials.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of complex drug candidates, particularly those requiring fluorinated motifs for enhanced metabolic stability and bioavailability.
• Agrochemical Research: Used in the development of new-generation herbicides, fungicides, and pesticides where the indole and fluorine components contribute to biological activity.
• Peptide Mimetics & Conjugation: The activated ester is employed in peptide synthesis and for bioconjugation strategies, linking payloads to targeting molecules.
• Material Science Precursor: Serves as a monomer or precursor in the creation of specialty polymers and organic electronic materials with unique fluorinated properties.
• Chemical Biology Probes: Utilized to create fluorescent tags, affinity labels, and other molecular probes for studying biological systems.
• Custom Synthesis & Contract Manufacturing: A critical reagent for custom synthesis houses producing bespoke compounds for client R&D programs.

Basic Information

Product Name	Pentafluorophenyl 1-Methyl-1H-Indole-7-Carboxylate
CAS No.	941716-96-7
Molecular Formula	C17H8F5NO2
Molecular Weight	353.25 g/mol
Synonyms	1-Methyl-1H-indole-7-carboxylic acid pentafluorophenyl ester; Pentafluorophenyl 1-methylindole-7-carboxylate; 7-(Pentafluorophenoxycarbonyl)-1-methylindole; 1-Methyl-7-indolecarboxylic acid pentafluorophenyl ester; PFP-1-Me-Indole-7-CO2 ester; CAS 941716-96-7
EINECS	Contact for details

Quality Control

Our Pentafluorophenyl 1-Methyl-1H-Indole-7-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the high standards required for research and process chemistry. A comprehensive Certificate of Analysis (COA) detailing purity, impurities, and physical characteristics is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Keep the container tightly sealed in a desiccator when not in use.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.