Description

3-(4-(7H-Pyrrolo[2,3-D]Pyrimidin-4-Yl)-1H-Pyrazol-1-Yl)-3-Cyclopentylpropanenitrile is a high-purity, advanced pharmaceutical intermediate belonging to the heterocyclic nitrile class. This compound is of significant commercial interest due to its role as a key building block in the synthesis of targeted kinase inhibitors and other bioactive molecules. It is primarily required by research institutions and pharmaceutical manufacturers engaged in the development of novel therapeutics for oncology and inflammatory diseases.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of small-molecule kinase inhibitors and other targeted therapies.
• Oncology Research: Used in the research and development of novel anti-cancer drug candidates, particularly those targeting specific protein kinases.
• Biochemical Research: Serves as a valuable reference standard and building block in medicinal chemistry and structure-activity relationship (SAR) studies.
• Process Development: Employed in the scale-up and optimization of synthetic routes for active pharmaceutical ingredients (APIs) under GMP conditions.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects.

Basic Information

Item	Detail
Product Name	3-(4-(7H-Pyrrolo[2,3-D]Pyrimidin-4-Yl)-1H-Pyrazol-1-Yl)-3-Cyclopentylpropanenitrile
CAS No.	941688-05-7
Molecular Formula	C17H18N6
Molecular Weight	306.37 g/mol
Synonyms	3-Cyclopentyl-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]propanenitrile; 3-(4-(7H-Pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)-3-cyclopentylpropionitrile; 941688-05-7; UNII-9J8F0X7A8T; 9J8F0X7A8T; 3-Cyclopentyl-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)pyrazol-1-yl]propanenitrile; 3-(4-(7H-Pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)-3-cyclopentyl-propanenitrile
EINECS	Contact for details

Quality Control

Our 3-(4-(7H-Pyrrolo[2,3-D]Pyrimidin-4-Yl)-1H-Pyrazol-1-Yl)-3-Cyclopentylpropanenitrile is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing to ensure identity, purity, and consistency, meeting the stringent requirements for pharmaceutical R&D and manufacturing. A comprehensive Certificate of Analysis (COA) detailing purity (typically >97% by HPLC), residual solvents, and related substances is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be handled under dry, inert conditions to prevent degradation. For long-term storage, consider storing under an inert atmosphere such as argon or nitrogen.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Single Maximum Impurity	≤ 1.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.