Description

4-(1H-Pyrazol-4-Yl)-7-((2-(Trimethylsilyl)Ethoxy)Methyl)-7H-Pyrrolo[2,3-D]Pyrimidine is a high-value, advanced pharmaceutical intermediate featuring a complex heterocyclic structure. This compound is critical for medicinal chemistry research and development, particularly in the synthesis of targeted kinase inhibitors. It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in the production of novel therapeutic agents.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of kinase inhibitors for oncology and inflammatory disease research.
• Medicinal Chemistry: Used in structure-activity relationship (SAR) studies and lead optimization for drug discovery programs.
• Biochemical Research: Serves as a precursor or reference standard in enzymatic assays and target validation studies.
• Custom Synthesis: Employed in the contract development and manufacturing (CDMO) of complex active pharmaceutical ingredients (APIs).
• Chemical Biology: Useful for creating chemical probes to study specific biological pathways and protein functions.

Basic Information

Product Name	4-(1H-Pyrazol-4-Yl)-7-((2-(Trimethylsilyl)Ethoxy)Methyl)-7H-Pyrrolo[2,3-D]Pyrimidine
CAS No.	941685-27-4
Molecular Formula	C15H21N5OSi
Molecular Weight	315.45 g/mol
Synonyms	7-((2-(Trimethylsilyl)ethoxy)methyl)-4-(1H-pyrazol-4-yl)-7H-pyrrolo[2,3-d]pyrimidine; 4-(1H-Pyrazol-4-yl)-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidine; 941685-27-4; Pyrrolo[2,3-d]pyrimidine, 4-(1H-pyrazol-4-yl)-7-[(2-(trimethylsilyl)ethoxy)methyl]-; TEM-Pyrrolopyrimidine intermediate; Kinase inhibitor intermediate; PROTAC linker precursor
EINECS	Contact for details

Quality Control

Our 4-(1H-Pyrazol-4-Yl)-7-((2-(Trimethylsilyl)Ethoxy)Methyl)-7H-Pyrrolo[2,3-D]Pyrimidine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the stringent requirements of pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider using desiccants or storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.