Description

2-Bromo-4-[(trifluoromethyl)sulphanyl]aniline, also known as 4-amino-3-bromophenyl trifluoromethyl sulphide, is a high-value, multifunctional aromatic amine building block. Its molecular structure, featuring both a reactive amino group and a stable, lipophilic trifluoromethylthio (SCF₃) moiety, makes it a critical intermediate for synthesizing advanced materials and bioactive compounds. This compound is primarily sought by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for creating novel molecules with enhanced properties.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly those targeting central nervous system (CNS) disorders, inflammation, and infectious diseases, where the SCF₃ group can improve metabolic stability and membrane permeability.
• Agrochemical Synthesis: Used in the research and production of next-generation herbicides, fungicides, and insecticides, where the bromine and amino groups allow for further functionalization to create compounds with specific modes of action.
• Material Science Precursor: Serves as a monomer or functionalizing agent in the synthesis of specialty polymers, liquid crystals, and organic electronic materials, leveraging the unique electronic properties of the trifluoromethylthio group.
• Chemical Biology Probe Development: Employed in medicinal chemistry to create molecular probes and labeled compounds for studying biological pathways and target engagement, thanks to its versatile reactivity.
• Cross-Coupling Reactions: The bromine substituent makes it an excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Sonogashira), enabling rapid diversification of chemical libraries.

Basic Information

Item	Details
Product Name	2-Bromo-4-[(trifluoromethyl)sulphanyl]aniline
CAS No.	940077-66-7
Molecular Formula	C7H5BrF3NS
Molecular Weight	272.09 g/mol
Synonyms	4-Amino-3-bromophenyl trifluoromethyl sulphide; 3-Bromo-4-aminophenyl trifluoromethyl sulfide; 2-Bromo-4-(trifluoromethylthio)aniline; 4-Amino-3-bromo-α,α,α-trifluorothioanisole; 940077-66-7; Benzenamine, 2-bromo-4-[(trifluoromethyl)thio]-; 2-Bromo-4-(trifluoromethylsulfanyl)aniline
EINECS	Contact for details

Quality Control

Every batch of 2-Bromo-4-[(trifluoromethyl)sulphanyl]aniline is manufactured and tested under a strict quality management system. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing key parameters such as purity (by HPLC), identity confirmation (by IR and NMR), and impurity profiles. Our quality commitment ensures the material meets the stringent requirements for research and scale-up applications in regulated industries.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.