Description

3-(6-Chloro-Pyrimidin-4-Ylamino)-Piperidine-1-Carboxylic Acid tert-Butyl Ester is a high-purity, advanced pharmaceutical intermediate (API intermediate) with a molecular formula of C14H21ClN4O2 and a molecular weight of 312.80. This compound is critical for the synthesis of complex active pharmaceutical ingredients (APIs), particularly in kinase inhibitor research and development. It is essential for medicinal chemists and process development scientists in the pharmaceutical, biotechnology, and fine chemical industries seeking reliable, high-quality building blocks for drug discovery and scale-up.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of kinase inhibitors and other targeted therapeutic agents.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies for novel drug candidates.
• Process Chemistry & Scale-Up: Serves as a critical raw material for the pilot-scale and commercial-scale manufacturing of active pharmaceutical ingredients (APIs).
• Bioconjugation & Probe Development: Utilized in the creation of chemical probes and labeled compounds for biochemical and cellular assays.
• Custom Synthesis: A starting material for the contract manufacturing of specialized fine chemicals and bespoke molecular entities.

Basic Information

Product Name	3-(6-Chloro-Pyrimidin-4-Ylamino)-Piperidine-1-Carboxylic Acid tert-Butyl Ester
CAS No.	939986-77-3
Molecular Formula	C14H21ClN4O2
Molecular Weight	312.80 g/mol
Synonyms	tert-Butyl 3-[(6-chloropyrimidin-4-yl)amino]piperidine-1-carboxylate; 1-Boc-3-[(6-chloro-4-pyrimidinyl)amino]piperidine; 3-[(6-Chloro-4-pyrimidinyl)amino]-1-piperidinecarboxylic Acid 1,1-Dimethylethyl Ester; 3-(6-Chloro-pyrimidin-4-ylamino)-piperidine-1-carboxylic acid tert-butyl ester; 939986-77-3; 1-Piperidinecarboxylic acid, 3-[(6-chloro-4-pyrimidinyl)amino]-, 1,1-dimethylethyl ester
EINECS	Contact for details

Quality Control

Our 3-(6-Chloro-Pyrimidin-4-Ylamino)-Piperidine-1-Carboxylic Acid tert-Butyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure a purity of 98+% and compliance with stringent internal specifications. Certificates of Analysis (COA) with full traceability are provided to guarantee reproducible quality and support your regulatory filings.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed and under an inert atmosphere if necessary to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.