Description

6-Chloropyrimidine-4-Carbonitrile is a versatile and high-value heterocyclic building block essential for advanced organic synthesis. Its unique structure, featuring both a reactive chlorine atom and a nitrile group on the pyrimidine core, makes it a critical intermediate for constructing complex molecules. This compound is primarily sought after by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the development of new active ingredients.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly for kinase inhibitors, antiviral agents, and other small-molecule therapeutics.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides, leveraging its heterocyclic scaffold for bioactivity.
• Material Science: Serves as a building block for creating specialized polymers, ligands for catalysis, and organic electronic materials.
• Chemical Synthesis: Employed in cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) and nucleophilic aromatic substitution to introduce the pyrimidine moiety into more complex structures.
• Academic & Contract Research: Utilized in university and CRO laboratories for methodological development and exploratory chemistry projects.

Basic Information

Product Name	6-Chloropyrimidine-4-Carbonitrile
CAS No.	939986-65-9
Molecular Formula	C5H2ClN3
Molecular Weight	139.54 g/mol
Synonyms	4-Cyano-6-chloropyrimidine; 6-Chloro-4-pyrimidinecarbonitrile; 6-Chloro-4-cyanopyrimidine; 6-Chloropyrimidine-4-carbonitrile; 6-Chloro-4-pyrimidine carbonitrile; 4-Pyrimidinecarbonitrile, 6-chloro-; 6-Chloro-4-cyano-pyrimidine
EINECS	Contact for details

Quality Control

Every batch of 6-Chloropyrimidine-4-Carbonitrile is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the compound meets the high-purity standards required for research and development. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles by HPLC, NMR, and MS is supplied with each shipment to guarantee batch-to-batch consistency and reliability for your critical syntheses.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.