Description

2-(Chloromethyl)-5-Fluorobenzenamine is a versatile aromatic amine derivative featuring both chloromethyl and fluoro substituents, making it a valuable bifunctional building block in advanced organic synthesis. Its molecular structure is engineered to facilitate nucleophilic substitution and serve as a key precursor for constructing complex heterocyclic and pharmaceutical scaffolds. This intermediate is primarily sought by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for the development of new active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders and oncological pathways.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and insecticides, leveraging its halogenated structure for bioactivity.
• Ligand and Catalyst Preparation: Serves as a starting material for synthesizing specialized ligands used in catalytic processes and metal-organic frameworks (MOFs).
• Functional Material Development: Employed in the research and production of advanced polymers, liquid crystals, and organic electronic materials.
• Custom Chemical Synthesis: A versatile building block for contract research organizations (CROs) and CDMOs producing bespoke compounds for client projects.
• Fluorescent Dye and Sensor Chemistry: Acts as a core component in the synthesis of fluorophores and molecular sensors for analytical and diagnostic applications.

Basic Information

Product Name	2-(Chloromethyl)-5-Fluorobenzenamine
CAS No.	939758-35-7
Molecular Formula	C7H7ClFN
Molecular Weight	159.59 g/mol
Synonyms	5-Fluoro-2-(chloromethyl)aniline; 2-Amino-4-fluorobenzyl chloride; 1-(Chloromethyl)-4-fluoro-2-aminobenzene; 4-Fluoro-2-aminobenzyl chloride; (5-Fluoro-2-aminophenyl)methyl chloride; 2-(Chloromethyl)-5-fluoroaniline; 5-Fluoro-2-aminobenzyl chloride; Benzenamine, 2-(chloromethyl)-5-fluoro-
EINECS	Contact for details

Quality Control

Every batch of 2-(Chloromethyl)-5-Fluorobenzenamine is manufactured under strict quality management systems and undergoes rigorous analytical testing to ensure identity, purity, and consistency. Our standard pharmaceutical intermediate grade is characterized by HPLC, GC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with each shipment. We support compliance with ICH Q7 guidelines and can tailor specifications to meet specific customer and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (typically 15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, containers must be kept tightly sealed and consideration should be given to storage under an inert atmosphere for long-term preservation of quality. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.