Description

Pyrido[2,3-D]Pyrimidine, 7-Chloro-2-[(2R,6S)-2,6-Dimethyl-4-Morpholinyl]-4-(4-Morpholinyl)-, Rel- is a sophisticated, stereochemically defined heterocyclic compound that serves as a critical building block in modern pharmaceutical research and development. Its complex molecular architecture, featuring dual morpholine substituents, makes it a valuable intermediate for the synthesis of targeted small molecule therapeutics. This high-purity intermediate is essential for medicinal chemists and process development scientists working in oncology, kinase inhibitor programs, and other advanced drug discovery pipelines.

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the development of novel kinase inhibitors and other targeted cancer therapies.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization campaigns due to its privileged scaffold.
• Process Chemistry & Scale-Up: Serves as a critical intermediate for the cGMP manufacture of active pharmaceutical ingredients (APIs) under development.
• Biochemical Tool Compound: Utilized in biochemical assays and high-throughput screening to study specific biological pathways and target engagement.
• Custom Synthesis Building Block: Employed by contract research and manufacturing organizations (CROs/CMOs) for the custom synthesis of complex molecules for clients.

Basic Information

Product Name	Pyrido[2,3-D]Pyrimidine, 7-Chloro-2-[(2R,6S)-2,6-Dimethyl-4-Morpholinyl]-4-(4-Morpholinyl)-, Rel-
CAS No.	938443-23-3
Molecular Formula	C17H24ClN5O2
Molecular Weight	365.86 g/mol
Synonyms	rel-7-Chloro-2-[(2R,6S)-2,6-dimethyl-4-morpholinyl]-4-(4-morpholinyl)pyrido[2,3-d]pyrimidine; (rel)-7-Chloro-2-((2R,6S)-2,6-dimethylmorpholino)-4-morpholinopyrido[2,3-d]pyrimidine; 938443-23-3; 7-Chloro-2-[(2R,6S)-2,6-dimethyl-4-morpholinyl]-4-(4-morpholinyl)pyrido[2,3-d]pyrimidine (rel); UNII-9J3U6Q0K8W; 9J3U6Q0K8W; SCHEMBL21806227; DTXSID60664608
EINECS	Contact for details

Quality Control

Our Pyrido[2,3-D]Pyrimidine intermediate is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research and development use. Each lot undergoes comprehensive analytical characterization, including HPLC for purity and chiral purity, NMR, and mass spectrometry for structural confirmation. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment to support your regulatory and quality documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The compound may be hygroscopic; keep the container tightly sealed in a dry environment to prevent moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.