Description

2-(2,2-Difluoroethoxy)-5-Fluoroaniline is a specialized fluorinated aniline derivative, serving as a critical building block in advanced organic synthesis. Its value lies in the unique reactivity of its aniline group combined with the electronic and steric properties imparted by the difluoroethoxy substituent, enabling the construction of complex molecular architectures. This high-purity intermediate is essential for research and development in the pharmaceutical and agrochemical industries, particularly for creating novel active ingredients.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), especially for candidates targeting central nervous system (CNS) disorders, oncology, and anti-infectives.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides, where the fluorine atoms enhance biological activity and environmental stability.
• Liquid Crystal & OLED Materials: Serves as a building block for fluorinated components in electronic display materials, improving charge transport and thermal stability.
• Polymer Modification: Employed to introduce fluorinated aniline moieties into polymer backbones, altering surface properties, chemical resistance, and dielectric characteristics.
• Organic Synthesis Research: A versatile reagent for academic and industrial R&D in medicinal chemistry and material science for constructing complex heterocycles and functional molecules.

Basic Information

Product Name	2-(2,2-Difluoroethoxy)-5-Fluoroaniline
CAS No.	937596-97-9
Molecular Formula	C8H8F3NO
Molecular Weight	191.15 g/mol
Synonyms	5-Fluoro-2-(2,2-difluoroethoxy)aniline; 2-Amino-4-fluoro-1-(2,2-difluoroethoxy)benzene; 1-(2,2-Difluoroethoxy)-4-fluoro-2-aminobenzene; 5-Fluoro-2-(2,2-difluoroethoxy)benzenamine; 2-(2,2-Difluoroethoxy)-5-fluoro-benzenamine; 937596-97-9; 2,2-Difluoroethoxy-5-fluoroaniline
EINECS	Contact for details

Quality Control

We supply 2-(2,2-Difluoroethoxy)-5-Fluoroaniline in high-purity grades suitable for demanding synthetic applications. Our production follows strict quality management protocols to ensure batch-to-batch consistency and reliability. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles, generated using validated analytical methods (HPLC, GC, NMR). We support compliance with cGMP and ISO standards for pharmaceutical and industrial customers.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from heat, open flames, and incompatible materials such as strong oxidizing agents. Due to its light-sensitive nature, containers should be amber-colored or stored in light-resistant secondary packaging.

Specification

Item	Specification
Appearance	Light yellow to brown crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.