Description

4-Pyrimidinamine, n-[5-[(1E)-2-(7-Chloro-1H-Indol-4-Yl)Ethenyl]-2-Thiazolyl]-2-Methyl-6-(1-Piperazinyl)- is a sophisticated heterocyclic organic compound featuring a unique molecular architecture combining pyrimidine, indole, thiazole, and piperazine moieties. This complex structure makes it a valuable advanced pharmaceutical intermediate for research and development in medicinal chemistry. It is primarily utilized by pharmaceutical R&D laboratories and fine chemical synthesis facilities focused on developing novel therapeutic agents.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of novel drug candidates, particularly for targeted therapies.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies to optimize biological activity and pharmacokinetic properties.
• Kinase Inhibitor Development: The structural motifs suggest potential application in the research of protein kinase inhibitors for oncology and inflammatory diseases.
• Chemical Biology Probes: Employed in the design and synthesis of molecular probes to study specific biological pathways and target validation.
• Custom Synthesis: A critical starting material for contract research organizations (CROs) and CDMOs engaged in custom synthesis projects.
• Academic Research: Used in university and institutional labs for fundamental research in organic synthesis and heterocyclic chemistry.

Basic Information

Product Name	4-Pyrimidinamine, n-[5-[(1E)-2-(7-Chloro-1H-Indol-4-Yl)Ethenyl]-2-Thiazolyl]-2-Methyl-6-(1-Piperazinyl)-
CAS No.	936845-71-5
Molecular Formula	C22H22ClN7S
Molecular Weight	451.98 g/mol
Synonyms	N-[5-[(E)-2-(7-Chloro-1H-indol-4-yl)ethenyl]-1,3-thiazol-2-yl]-2-methyl-6-(piperazin-1-yl)pyrimidin-4-amine; 2-Methyl-6-(piperazin-1-yl)-N-[5-[(E)-2-(7-chloro-1H-indol-4-yl)vinyl]-1,3-thiazol-2-yl]pyrimidin-4-amine; 936845-71-5; 4-Pyrimidinamine, N-[5-[(1E)-2-(7-chloro-1H-indol-4-yl)ethenyl]-2-thiazolyl]-2-methyl-6-(1-piperazinyl)-; A high-potency kinase inhibitor intermediate.
EINECS	Contact for details

Quality Control

Our production of this high-value intermediate adheres to strict quality management systems. Every batch undergoes comprehensive analytical characterization using techniques including HPLC, NMR, and MS to confirm identity and purity. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting critical quality attributes. We support development projects with cGMP-compliant synthesis and quality documentation as required.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). This compound is light-sensitive (store away from light) and may be hygroscopic (moisture-sensitive); therefore, containers should be kept tightly sealed under inert atmosphere if necessary to prevent degradation. Keep away from strong acids and oxidizing agents.

Specification

Item	Specification
Appearance	Off-white to light yellow solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.