Description

Cyclo(His-Pro) (Tfa) is a synthetic, cyclic dipeptide derivative where the histidine-proline dipeptide is cyclized and modified with a trifluoroacetyl (Tfa) protecting group. This compound is of significant interest in biochemical and pharmaceutical research due to its role as a precursor or model compound for studying neuropeptides and metabolic regulators. It is primarily utilized by research institutions and pharmaceutical developers engaged in peptide chemistry, neuroscience, and drug discovery programs. The product is supplied as a high-purity material suitable for advanced laboratory applications.

Application

• Biochemical Research: Used as a reference standard or intermediate in the study of cyclic dipeptides (diketopiperazines) and their biological activities.
• Neuroscience Studies: Serves as a tool compound for investigating the structure-activity relationships of histidine-containing neuropeptides.
• Pharmaceutical Development: Acts as a key synthetic building block or protected intermediate in the preparation of more complex peptide-based drug candidates.
• Metabolic Research: Employed in studies exploring the role of cyclic dipeptides in metabolic pathways and signaling.
• Academic & Industrial R&D: Essential for method development, analytical testing, and purity assessment in peptide synthesis workflows.

Basic Information

Product Name	Cyclo(His-Pro) (Tfa)
CAS No.	936749-56-3
Molecular Formula	C14H15F3N4O4
Molecular Weight	360.29 g/mol
Synonyms	Cyclo(L-Histidyl-L-Prolyl) Trifluoroacetate; Cyclo(His-Pro) Trifluoroacetate Salt; L-Histidyl-L-Proline Cyclic Dipeptide TFA; 3,6-Di(1H-imidazol-4-ylmethyl)-2,5-diketopiperazine Trifluoroacetate; Histidyl-Proline Diketopiperazine (Tfa); cHP TFA; Cyclo(His-Pro) TFA Salt; Cyclo(L-His-L-Pro) x CF3COOH
EINECS	Contact for details

Quality Control

Our Cyclo(His-Pro) (Tfa) is manufactured under controlled conditions to ensure high purity and batch-to-batch consistency. Each lot undergoes rigorous analytical testing, including HPLC for purity assessment and NMR/IR for structural confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our quality management system supports compliance with the standards required for research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.