Description

Lcz696 CAS NO 936623-90-4 is a high-purity, non-proprietary active pharmaceutical ingredient (API) and a key chemical intermediate. This compound is of significant commercial and research interest due to its role as a combination drug substance. It is primarily utilized by pharmaceutical manufacturers and advanced research institutions engaged in cardiovascular drug development and formulation studies.

Application

• Pharmaceutical API Synthesis: Serves as the core active ingredient in the manufacture of combination cardiovascular medications.
• Cardiovascular Research: Used as a critical reference standard and intermediate in preclinical and clinical research for heart failure and hypertension.
• Formulation Development: Employed in the development and testing of solid dosage forms, such as tablets, requiring precise API characterization.
• Analytical Standard: Provides a high-purity standard for quality control (QC) and analytical method development (e.g., HPLC, LC-MS) in pharmaceutical labs.
• Chemical Intermediate: Acts as a sophisticated building block for further synthetic modification in specialized medicinal chemistry programs.
• Regulatory Submissions: Supplied as a well-characterized substance to support regulatory filings (e.g., DMF, CMC sections) with agencies like the FDA and EMA.

Basic Information

Product Name	Lcz696
CAS No.	936623-90-4
Molecular Formula	C48H55N6O8Na2
Molecular Weight	873.0 g/mol
Synonyms	LCZ 696; LCZ-696; Sacubitril and Valsartan Sodium Salt Complex; Valsartan/Sacubitril Sodium Salt; AHU-377/Valsartan Sodium Salt; (2R,4S)-5-Biphenyl-4-yl-4-(3-carboxy-propionylamino)-2-methyl-pentanoic acid [1-(1H-tetrazol-5-yl)-2'-(2H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-amide sodium salt; Entresto API (non-proprietary)
EINECS	Contact for details

Quality Control

Our Lcz696 is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and consistency, meeting high-grade pharmaceutical standards. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting key parameters such as assay, related substances, and residual solvents. We support compliance with ICH Q7 guidelines and can tailor specifications to meet specific pharmacopeial or client requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under dry, inert conditions to maintain stability and potency. The original container should be resealed immediately after use to minimize exposure to atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0% (on anhydrous basis)
Water Content (KF)	≤ 5.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single unknown impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.