Description

Indolidan is a selective phosphodiesterase III (PDE III) inhibitor, a high-purity pharmaceutical intermediate and research chemical with significant biological activity. Its primary value lies in its potent inotropic and vasodilatory effects, making it a critical compound for cardiovascular research and drug development. This product is essential for pharmaceutical R&D laboratories, academic institutions, and manufacturers focused on developing novel therapeutic agents for heart failure and related cardiac conditions.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of advanced cardiovascular drug candidates.
• Biomedical Research: Used as a reference standard and active agent in studies investigating PDE III inhibition mechanisms.
• Cardiac Pharmacology: Employed in in vitro and in vivo models to study positive inotropic effects and vasodilation.
• Drug Discovery & Development: Serves as a lead compound or pharmacophore model for designing new heart failure medications.
• Biochemical Assays: Utilized in enzymatic assays to screen for PDE III activity and inhibitor potency.
• Academic & Clinical Research: Supports fundamental research into cyclic nucleotide signaling pathways and their role in cardiovascular physiology.

Basic Information

Product Name	Indolidan
CAS No.	100643-96-7
Molecular Formula	C20H19N3O4
Molecular Weight	365.38 g/mol
Synonyms	LY195115; 1,3-Dihydro-3,3-dimethyl-5-(1,4,5,6-tetrahydro-6-oxo-3-pyridazinyl)-2H-indol-2-one; Indolidane; 5-(1,4,5,6-Tetrahydro-6-oxo-3-pyridazinyl)-3,3-dimethyl-1,3-dihydro-2H-indol-2-one; PDE III Inhibitor LY195115
EINECS	Contact for details

Quality Control

Our Indolidan is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research and development. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. We adhere to cGMP principles where applicable, and our quality protocols are designed to meet the stringent requirements of the pharmaceutical and biotechnology industries.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). The product is moisture-sensitive; keep the container tightly sealed in a dry environment. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.