Description

Milrinone is a potent bipyridine derivative and selective phosphodiesterase 3 (PDE3) inhibitor. It is a critical pharmaceutical intermediate and active pharmaceutical ingredient (API) used in the development of cardiovascular therapeutics. This compound is essential for manufacturers and research institutions focused on producing and studying inotropic agents for the treatment of acute heart failure. Milrinone CAS NO 78415-72-2 is supplied under stringent quality control to ensure reliability for sensitive pharmaceutical applications.

Application

• Pharmaceutical API: Primary use as the active ingredient in the formulation of intravenous medications for short-term heart failure management.
• Cardiovascular Research: A key reference standard and tool compound in preclinical and clinical research studying cardiac contractility and PDE3 inhibition.
• Chemical Synthesis: Serves as a crucial synthetic intermediate for the production of novel PDE3 inhibitor analogs and related pharmacologically active molecules.
• Analytical Standard: Used as a high-purity certified reference material (CRM) in quality control laboratories for HPLC, LC-MS, and other analytical method development and validation.
• GMP Manufacturing: Supplied to cGMP-compliant facilities for the production of finished dosage forms, ensuring traceability and regulatory compliance.

Basic Information

Product Name	Milrinone
CAS No.	78415-72-2
Molecular Formula	C12H9N3O
Molecular Weight	211.22 g/mol
Synonyms	1,6-Dihydro-2-methyl-6-oxo-[3,4'-bipyridine]-5-carbonitrile; Win 47203; Corotrope; Primacor; 2-Methyl-5-cyano-1,6-dihydro-6-oxo-[3,4'-bipyridine]; 5-Cyano-1,6-dihydro-2-methyl-6-oxo-3,4'-bipyridine
EINECS	Contact for details

Quality Control

Our Milrinone is manufactured and tested to meet the highest standards for pharmaceutical use. Quality is assured through a comprehensive battery of tests including identity confirmation, purity assay, and impurity profiling. We provide full traceability and support regulatory filings with detailed documentation. Certificates of Analysis (COA) are available for every batch, confirming compliance with relevant specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Related Substances (HPLC)	Total impurities ≤ 1.0% Any single impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.