Description

7-Hydroxydigitoxin is a hydroxylated derivative of the cardiac glycoside digitoxin, representing a key intermediate and reference standard in pharmaceutical research and development. This compound is of significant interest for its role in the study of cardiotonic drug metabolism, structure-activity relationships, and biosynthetic pathways. It is primarily utilized by research institutions, pharmaceutical companies, and analytical laboratories engaged in cardiovascular drug discovery, pharmacokinetic studies, and the quality control of related botanical extracts.

Application

• Pharmaceutical Reference Standard: Serves as a high-purity certified reference material (CRM) for the qualitative and quantitative analysis of digitalis glycosides and their metabolites in drug substances and finished products.
• Metabolite Studies: Used as a critical standard in pharmacokinetic and metabolic pathway research to understand the biotransformation of digitoxin and related compounds in biological systems.
• Biochemical Research: Employed as a tool compound in enzymology and molecular biology to investigate the mechanisms of action of cardiac glycosides on sodium-potassium ATPase pumps.
• Process Development: Acts as an intermediate or marker in the development and optimization of synthetic or semi-synthetic routes for novel cardiotonic agents.
• Quality Control (QC) & Assurance (QA): Essential for the identification and assay of related substances in bulk active pharmaceutical ingredients (APIs) and botanical drug preparations derived from *Digitalis* species.

Basic Information

Product Name	7-Hydroxydigitoxin
CAS No.	18810-27-0
Molecular Formula	C₄₁H₆₄O₁₄
Molecular Weight	781.0 g/mol
Synonyms	7β-Hydroxydigitoxin; Digitoxin, 7-hydroxy-; 3β-[(O-2,6-Dideoxy-β-D-ribo-hexopyranosyl-(1→4)-O-2,6-dideoxy-β-D-ribo-hexopyranosyl-(1→4)-2,6-dideoxy-β-D-ribo-hexopyranosyl)oxy]-14-hydroxy-5β-card-20(22)-enolide; 7-Hydroxy-digitoxin; 7-OH-Digitoxin
EINECS	Contact for details

Quality Control

Our 7-Hydroxydigitoxin is manufactured and tested under a strict quality management system. Each batch is subjected to comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the high standards required for pharmaceutical research. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting batch-specific results.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; ensure the container is sealed tightly after each use to minimize exposure to atmospheric moisture and light.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 2.0%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.