Description

Olprinonehcl is a selective phosphodiesterase III (PDE III) inhibitor, supplied as its hydrochloride salt. This compound is a key pharmaceutical intermediate and reference standard in the research and development of cardiotonic agents. It is primarily utilized by pharmaceutical manufacturers and research institutions focused on cardiovascular therapeutics. The material is characterized by its high purity and is essential for ensuring the quality and efficacy of related drug products.

Application

• Pharmaceutical Intermediate: Critical synthesis component for the production of the active pharmaceutical ingredient (API) Olprinone.
• Reference Standard: Used in analytical laboratories for quality control, method validation, and regulatory compliance testing of Olprinone-based formulations.
• Biochemical Research: Serves as a tool compound in pharmacological studies to investigate PDE III inhibition mechanisms and cardiac function.
• Drug Development: Employed in pre-clinical and clinical research for developing new cardiotonic and vasodilatory therapies.
• Impurity Standard: Used to identify and quantify related substances during the stability testing and specification setting of pharmaceutical products.

Basic Information

Product Name	Olprinonehcl
CAS No.	106730-54-0
Molecular Formula	C₁₄H₁₀N₆O·HCl
Molecular Weight	314.73 g/mol
Synonyms	Olprinone Hydrochloride; 1,2-Dihydro-5-imidazo[1,2-a]pyridin-6-yl-6-methyl-2-oxo-3-pyridinecarbonitrile Hydrochloride; 6-Methyl-2-oxo-5-(imidazo[1,2-a]pyridin-6-yl)-1,2-dihydropyridine-3-carbonitrile Hydrochloride; E-1020; E1020; E-1020 Hydrochloride; PDE III Inhibitor E1020
EINECS	Contact for details

Quality Control

Our Olprinonehcl is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, residual solvent analysis, and identification by spectroscopic methods, to ensure it meets stringent specifications for pharmaceutical use. Certificates of Analysis (COA) detailing all test results are provided with every shipment to guarantee traceability and compliance with your quality requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after each use to prevent moisture absorption, which may affect stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Related Substances (HPLC)	Total impurities ≤2.0%; Any single impurity ≤0.5%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.