Description

Acetyldigitoxin is a semi-synthetic cardiac glycoside derived from digitoxin, characterized by its acetylated structure. This compound is a critical intermediate and reference standard in pharmaceutical research and development, particularly for cardiovascular drug studies. It is primarily utilized by research institutions, pharmaceutical manufacturers, and analytical laboratories engaged in the synthesis and quality control of cardiac medications.

Application

• Pharmaceutical Reference Standard: Used as a high-purity certified reference material (CRM) for analytical method development, validation, and quality control testing of related drug substances and products.
• Cardiovascular Research: Serves as a key biochemical tool in pharmacological studies to investigate the mechanisms of action, metabolism, and structure-activity relationships of cardiac glycosides.
• Active Pharmaceutical Ingredient (API) Intermediate: Employed in the controlled synthesis and production of more complex cardiac therapeutic agents.
• Metabolite Studies: Used in in vitro and in vivo studies to understand the metabolic pathways and pharmacokinetics of digitoxin and related compounds.
• Analytical Chemistry: Acts as a critical standard in chromatographic analyses (HPLC, LC-MS) for the identification and quantification of glycosides in complex matrices.

Basic Information

Product Name	Acetyldigitoxin
CAS No.	1111-39-3
Molecular Formula	C43H66O14
Molecular Weight	806.97 g/mol
Synonyms	Acetyldigitoxin; 3β-[(O-2,6-Dideoxy-β-D-ribo-hexopyranosyl-(1→4)-O-2,6-dideoxy-β-D-ribo-hexopyranosyl-(1→4)-2,6-dideoxy-β-D-ribo-hexopyranosyl)oxy]-14-hydroxy-5β-card-20(22)-enolide 16-acetate; 16-Acetylgitoxin; α-Acetyldigitoxin; Gitoxin 16-acetate; NSC 107919; AY 15611
EINECS	Contact for details

Quality Control

Our Acetyldigitoxin is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (IR, MS), to ensure it meets the high standards required for research and development. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting all relevant specifications. We support compliance with various pharmacopeial and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a desiccated environment to maintain stability and purity. For long-term storage, consider inert atmosphere conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.