Description

(3S)-2-{[(9H-Fluoren-9-Yl)Methoxy]Carbonyl}-6-Hydroxy-1,2,3,4-Tetrahydroisoquinoline-3-Carboxylic Acid CAS NO 936545-85-6 is a sophisticated, optically pure Fmoc-protected amino acid derivative essential for advanced peptide synthesis. This compound serves as a critical building block for constructing complex peptide chains with high stereochemical fidelity, enabling the development of novel therapeutic agents and biochemical tools. It is primarily required by pharmaceutical R&D laboratories, biotechnology companies, and academic institutions engaged in peptide-based drug discovery and proteomics research.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key intermediate for the automated, sequential assembly of peptides on resin, particularly for introducing the constrained 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid (Tic) scaffold.
• Pharmaceutical Research & Development: Used in the synthesis of peptide-based drug candidates targeting GPCRs, enzymes, and other biological receptors where the Tic moiety can influence bioactivity and metabolic stability.
• Bioconjugation and Probe Development: Facilitates the site-specific incorporation of functional handles or labels into peptides for creating imaging probes, diagnostic tools, or antibody-drug conjugates (ADCs).
• Combinatorial Chemistry Libraries: Employed in the generation of diverse peptide libraries for high-throughput screening to identify new lead compounds with desired biological properties.
• Academic & Biochemical Research: Essential for studying protein-protein interactions, enzyme mechanisms, and structure-activity relationships (SAR) using synthetic peptide analogs.

Basic Information

Product Name	(3S)-2-{[(9H-Fluoren-9-Yl)Methoxy]Carbonyl}-6-Hydroxy-1,2,3,4-Tetrahydroisoquinoline-3-Carboxylic Acid
CAS No.	936545-85-6
Molecular Formula	C26H21NO6
Molecular Weight	443.45 g/mol
Synonyms	Fmoc-6-hydroxy-Tic-OH; Fmoc-6-hydroxy-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid; (3S)-2-(((9H-Fluoren-9-yl)methoxy)carbonyl)-6-hydroxy-1,2,3,4-tetrahydro-3-isoquinolinecarboxylic acid; N-α-Fmoc-6-hydroxy-L-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid; Fmoc-HOTic-OH; Fmoc-L-6-hydroxy-Tic-OH; N-Fmoc-6-hydroxy-L-tetrahydroisoquinoline-3-carboxylic acid
EINECS	Contact for details

Quality Control

Our (3S)-2-{[(9H-Fluoren-9-Yl)Methoxy]Carbonyl}-6-Hydroxy-1,2,3,4-Tetrahydroisoquinoline-3-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral integrity, to ensure it meets the high standards required for sensitive peptide synthesis applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and specific impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This compound is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0%
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.