Description

Methyl 2,6-Dioxo-5-(Trifluoromethyl)-1,2,3,6-Tetrahydro-4-Pyrimidinecarboxylate is a high-value, multi-functional heterocyclic building block characterized by its pyrimidinedione core and trifluoromethyl group. This compound is essential for the synthesis of novel active pharmaceutical ingredients (APIs) and advanced agrochemicals, where its unique structure imparts critical biological activity and metabolic stability. It is primarily sought after by research and development teams in the pharmaceutical, agrochemical, and specialty chemical industries for creating next-generation therapeutic and crop protection agents.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of novel small-molecule drugs, particularly for antiviral, anticancer, and anti-inflammatory applications.
• Agrochemical Synthesis: Serves as a crucial building block for developing advanced herbicides, fungicides, and insecticides with enhanced efficacy and environmental profiles.
• Chemical Research & Development: Used in academic and industrial R&D for exploring new chemical entities and synthesizing complex heterocyclic libraries for biological screening.
• Material Science Precursor: Potential use in the synthesis of specialty polymers and advanced materials requiring fluorinated heterocyclic components.
• Contract Manufacturing (CMO): Supplied to custom synthesis and contract manufacturing organizations for scale-up and production under cGMP conditions.

Basic Information

Product Name	Methyl 2,6-Dioxo-5-(Trifluoromethyl)-1,2,3,6-Tetrahydro-4-Pyrimidinecarboxylate
CAS No.	936476-63-0
Molecular Formula	C7H5F3N2O4
Molecular Weight	238.12 g/mol
Synonyms	5-(Trifluoromethyl)-1,2,3,6-tetrahydro-2,6-dioxo-4-pyrimidinecarboxylic acid methyl ester; Methyl 5-(trifluoromethyl)-1,2,3,6-tetrahydro-2,6-dioxopyrimidine-4-carboxylate; 4-Pyrimidinecarboxylic acid, 1,2,3,6-tetrahydro-2,6-dioxo-5-(trifluoromethyl)-, methyl ester; 5-Trifluoromethyl-1,2,3,6-tetrahydro-2,6-dioxo-4-pyrimidinecarboxylic acid methyl ester; Methyl 5-trifluoromethylbarbiturate-4-carboxylate
EINECS	Contact for details

Quality Control

Our production of Methyl 2,6-Dioxo-5-(Trifluoromethyl)-1,2,3,6-Tetrahydro-4-Pyrimidinecarboxylate adheres to stringent internal quality standards to ensure batch-to-batch consistency and high purity for research and commercial use. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with each shipment. We support development and scale-up projects with custom synthesis capabilities and can work towards specific customer requirements, including analytical method development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment to prevent degradation. Keep away from incompatible materials such as strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.