Description

(S)-1-(5-Fluoropyrimidin-2-yl)ethanamine hydrochloride is a high-purity chiral amine building block, specifically the hydrochloride salt of the (S)-enantiomer. This compound is a critical intermediate in modern pharmaceutical research and development, offering a defined stereocenter essential for creating targeted active pharmaceutical ingredients (APIs). It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries for the synthesis of novel therapeutic agents.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new drug candidates, particularly in kinase inhibitor programs.
• Active Pharmaceutical Ingredient (API) Synthesis: Used in the scalable production of enantiomerically pure APIs where the (S)-configuration is required for biological activity.
• Agrochemical Research: Serves as a building block for developing advanced, stereospecific pesticides and herbicides.
• Chemical Biology & Probe Development: Employed in the creation of molecular probes and tool compounds for studying biological pathways.
• Process Chemistry & Route Scouting: Used by process chemists to develop and optimize efficient, asymmetric synthetic routes.
• Custom Synthesis & Contract Manufacturing: A starting material for custom synthesis projects requiring high chiral purity and reliable supply.

Basic Information

Product Name	(S)-1-(5-Fluoropyrimidin-2-yl)ethanamine Hydrochloride
CAS No.	935667-21-3
Molecular Formula	C6H9FN3·HCl
Molecular Weight	191.62 g/mol (Free base: 155.16 g/mol)
Synonyms	(S)-1-(5-Fluoropyrimidin-2-yl)ethanamine HCl; (S)-1-(5-Fluoro-2-pyrimidinyl)ethylamine hydrochloride; (S)-α-Methyl-5-fluoropyrimidine-2-methanamine hydrochloride; (S)-2-(1-Aminoethyl)-5-fluoropyrimidine hydrochloride; 935667-21-3; (S)-Enantiomer of 1-(5-Fluoropyrimidin-2-yl)ethanamine HCl
EINECS	Contact for details

Quality Control

Our (S)-1-(5-Fluoropyrimidin-2-yl)ethanamine hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical R&D. A detailed Certificate of Analysis (COA) providing specifications for identity, assay, chiral purity, and related substances is available for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under inert conditions (e.g., nitrogen atmosphere) after opening to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (Chiral HPLC)	≥99.0% ee
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.