Description

4-Fluoro-2-Methoxybenzenesulfonyl Fluoride is a high-purity, specialized organosulfur building block of significant importance in advanced organic synthesis. Its core value lies in its dual functional groups, making it a versatile precursor for constructing complex sulfonamide and sulfonate derivatives. This compound is essential for research chemists and process development scientists in the pharmaceutical and agrochemical industries, where it is used to introduce the sulfonyl fluoride moiety into target molecules for drug discovery and crop protection agents.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of novel active pharmaceutical ingredients (APIs), particularly for kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides, leveraging the sulfonyl fluoride group for bioactivity.
• Chemical Biology Probe Development: Serves as a reactive handle in activity-based protein profiling (ABPP) and the development of covalent inhibitors for target identification and validation.
• Material Science Research: Employed as a monomer or cross-linking agent in the creation of specialty polymers with unique surface properties or chemical resistance.
• Suzuki-Miyaura & Other Cross-Coupling Reactions: The aromatic ring can be further functionalized via palladium-catalyzed cross-coupling to create diverse chemical libraries.
• Sulfonamide Library Synthesis: Reacts efficiently with various amines to generate focused libraries of sulfonamide compounds for high-throughput screening.

Basic Information

Product Name	4-Fluoro-2-Methoxybenzenesulfonyl Fluoride
CAS No.	935534-27-3
Molecular Formula	C7H6F2O3S
Molecular Weight	220.18 g/mol
Synonyms	2-Methoxy-4-fluorobenzenesulfonyl Fluoride; 4-Fluoro-2-methoxy-1-benzenesulfonyl Fluoride; 1-Fluoro-4-methoxy-2-sulfonylfluoride Benzene; 4-Fluoro-2-methoxyphenylsulfonyl Fluoride; 2-Methoxy-4-fluorophenylsulfonyl Fluoride; 935534-27-3; 4-Fluoro-2-methoxybenzene-1-sulfonyl fluoride
EINECS	Contact for details

Quality Control

Every batch of 4-Fluoro-2-Methoxybenzenesulfonyl Fluoride is manufactured under strict quality management systems and undergoes rigorous analytical testing to ensure consistency and high purity. Our standard grade meets typical research and development specifications, with Certificates of Analysis (COA) providing detailed results for purity and identity confirmation available for each lot. We support custom synthesis projects where specifications for purity, impurity profiles, and packaging can be tailored to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.