Description

2-Chloro-4-(2,2,2-trifluoroethoxy)pyrimidine is a high-value fluorinated pyrimidine derivative, serving as a critical building block in advanced organic synthesis. Its molecular structure, featuring both a chloro and a trifluoroethoxy substituent, makes it an essential intermediate for constructing complex molecules with tailored properties. This compound is primarily sought after by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs), agrochemicals, and specialty materials.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of potential drug candidates, particularly in medicinal chemistry programs targeting kinase inhibitors and other small molecule therapeutics.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides, where the trifluoroethoxy group can enhance biological activity and environmental stability.
• Liquid Crystal & OLED Material Precursor: Serves as a starting material for creating fluorinated heterocyclic compounds used in electronic display technologies.
• Custom Synthesis & Contract Manufacturing: Employed by CDMOs (Contract Development and Manufacturing Organizations) for the production of bespoke compounds for client R&D projects.
• Academic & Industrial R&D: Utilized in exploratory chemistry to study structure-activity relationships (SAR) and to create novel chemical libraries for screening.

Basic Information

Item	Details
Product Name	2-Chloro-4-(2,2,2-trifluoroethoxy)pyrimidine
CAS No.	935252-67-8
Molecular Formula	C6H4ClF3N2O
Molecular Weight	212.56 g/mol
Synonyms	4-(2,2,2-Trifluoroethoxy)-2-chloropyrimidine; 2-Chloro-4-(2,2,2-trifluoroethoxy)pyrimidine; 2-Chloro-4-trifluoroethoxypyrimidine; Pyrimidine, 2-chloro-4-(2,2,2-trifluoroethoxy)-; 935252-67-8
EINECS	Contact for details

Quality Control

Our 2-Chloro-4-(2,2,2-trifluoroethoxy)pyrimidine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with every shipment, documenting all critical quality attributes. Our production adheres to cGMP principles where applicable, supporting its use in regulated research and development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, the container should be opaque or stored in dark conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.