Description

4-Chloro-7-(4-Methylphenyl)Sulfonylpyrrolo[2,3-D]Pyrimidin-2-Amine is a high-purity, advanced pharmaceutical intermediate belonging to the pyrrolopyrimidine class of heterocyclic compounds. This compound is of significant commercial importance as a key building block in the synthesis of targeted kinase inhibitors and other bioactive molecules for pharmaceutical research and development. It is primarily utilized by medicinal chemists and process development scientists in the pharmaceutical and biotechnology industries for drug discovery programs.

Application

• Pharmaceutical Intermediate: A critical precursor in the multi-step synthesis of novel kinase inhibitors targeting various disease pathways.
• Medicinal Chemistry Research: Serves as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery.
• Biochemical Tool Compound: Used in the development of assay probes to study specific enzyme functions and cellular signaling mechanisms.
• Process Chemistry & Scale-Up: Employed in the development and optimization of robust, scalable synthetic routes for active pharmaceutical ingredients (APIs).
• Contract Research & Manufacturing (CRO/CMO): Supplied to service organizations supporting global pharmaceutical development pipelines.
• Academic Research: Utilized in university and institutional labs for fundamental research in organic synthesis and chemical biology.

Basic Information

Product Name	4-Chloro-7-(4-Methylphenyl)Sulfonylpyrrolo[2,3-D]Pyrimidin-2-Amine
CAS No.	934524-13-7
Molecular Formula	C₁₃H₁₁ClN₄O₂S
Molecular Weight	322.77 g/mol
Synonyms	4-Chloro-7-(p-tolylsulfonyl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine; 4-Chloro-7-(4-methylbenzenesulfonyl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine; 934524-13-7; 4-Chloro-7-tosyl-7H-pyrrolo[2,3-d]pyrimidin-2-amine; Pyrrolo[2,3-d]pyrimidin-2-amine, 4-chloro-7-[(4-methylphenyl)sulfonyl]-; 4-Chloro-7-(4-methylphenyl)sulfonyl-pyrrolo[2,3-d]pyrimidin-2-ylamine
EINECS	Contact for details

Quality Control

Our 4-Chloro-7-(4-Methylphenyl)Sulfonylpyrrolo[2,3-D]Pyrimidin-2-Amine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the high standards required for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing purity, impurities, and full characterization data is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The compound may be light-sensitive (store away from light) and hygroscopic (moisture-sensitive); therefore, containers should be kept sealed under inert atmosphere when not in use to prevent degradation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.