Description

3-Bromo-2-Methyl-7-(Trifluoromethyl)-4,5,6,7-Tetrahydropyrazolo[1,5-A]Pyrimidine is a high-purity, advanced pharmaceutical intermediate characterized by its unique heterocyclic structure incorporating bromine and trifluoromethyl functional groups. This compound is critical for medicinal chemistry research and development, offering a versatile building block for the synthesis of novel active pharmaceutical ingredients (APIs). It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries seeking to introduce specific halogenated and fluorinated motifs into target molecules.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of potential drug candidates, particularly in oncology, CNS, and anti-infective therapeutic areas.
• Medicinal Chemistry Research: Used as a scaffold for structure-activity relationship (SAR) studies and library synthesis due to its reactive bromine site and stable tetrahydropyrimidine core.
• Agrochemical Development: Acts as a building block for creating novel herbicides, fungicides, or insecticides that leverage the biological activity of pyrazolopyrimidine derivatives.
• Fluorinated Compound Synthesis: The trifluoromethyl group makes it valuable for developing compounds with enhanced metabolic stability, lipophilicity, and bioavailability.
• Chemical Biology Probes: Utilized in the design and synthesis of chemical probes for target identification and validation in biological systems.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects requiring specialized heterocyclic chemistry.

Basic Information

Product Name	3-Bromo-2-Methyl-7-(Trifluoromethyl)-4,5,6,7-Tetrahydropyrazolo[1,5-A]Pyrimidine
CAS No.	934063-79-3
Molecular Formula	C9H9BrF3N3
Molecular Weight	296.09 g/mol
Synonyms	3-Bromo-2-methyl-7-(trifluoromethyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine; 4,5,6,7-Tetrahydro-3-bromo-2-methyl-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine; 934063-79-3; Pyrazolo[1,5-a]pyrimidine, 3-bromo-4,5,6,7-tetrahydro-2-methyl-7-(trifluoromethyl)-; 3-Bromo-2-methyl-7-trifluoromethyl-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine
EINECS	Contact for details

Quality Control

Our 3-Bromo-2-Methyl-7-(Trifluoromethyl)-4,5,6,7-Tetrahydropyrazolo[1,5-A]Pyrimidine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment supports compliance with cGMP guidelines for advanced intermediates, ensuring reliability for your critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.