Description

2-(2,5-Difluorophenyl)Pyrimidine-5-Carboxylic Acid is a high-purity, multi-functional heterocyclic building block essential for advanced organic synthesis. This compound matters because it serves as a critical intermediate for constructing complex molecules with tailored biological and material properties. It is primarily needed by research and development teams in the pharmaceutical, agrochemical, and material science industries for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for the development of kinase inhibitors, antiviral agents, and other small-molecule drug candidates.
• Agrochemical Research: Used in the synthesis of novel herbicides, fungicides, and pesticides, leveraging the difluorophenyl and pyrimidine motifs for bioactivity.
• Material Science Precursor: Serves as a building block for organic electronic materials, such as ligands for OLEDs or conductive polymers.
• Chemical Biology Probe Development: Employed in the design and synthesis of molecular probes and labeled compounds for biochemical assays.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs and research institutions for bespoke synthesis projects and library production.

Basic Information

Product Name	2-(2,5-Difluorophenyl)Pyrimidine-5-Carboxylic Acid
CAS No.	933988-75-1
Molecular Formula	C11H6F2N2O2
Molecular Weight	236.18 g/mol
Synonyms	2-(2,5-Difluorophenyl)-5-pyrimidinecarboxylic acid; 5-Carboxy-2-(2,5-difluorophenyl)pyrimidine; 2-(2,5-Difluorophenyl)pyrimidine-5-carboxylic acid; 933988-75-1; 2,5-Difluorophenyl pyrimidine-5-carboxylic acid; Pyrimidine-5-carboxylic acid, 2-(2,5-difluorophenyl)-; 2-(2,5-Difluorophenyl)-1,3-diazine-5-carboxylic acid
EINECS	Contact for details

Quality Control

Our 2-(2,5-Difluorophenyl)Pyrimidine-5-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. Certificates of Analysis (COA) are provided with every shipment, detailing all relevant specifications. We support compliance with cGMP and ICH guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.