Description

2-(3,5-Difluorophenyl)Pyrimidine-5-Carboxylic Acid is a high-purity, multi-functional heterocyclic building block of significant commercial and research interest. Its core value lies in its precise molecular architecture, which serves as a critical intermediate in the synthesis of advanced pharmaceutical compounds and agrochemicals. This product is essential for R&D chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries seeking to develop novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of novel drug candidates, particularly in kinase inhibitor and other small-molecule therapeutic programs.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides, leveraging the biological activity of the difluorophenyl-pyrimidine scaffold.
• Material Science Research: Serves as a precursor for the development of organic electronic materials, ligands for metal-organic frameworks (MOFs), and specialty polymers.
• Chemical Biology & Proteomics: Employed as a building block for designing molecular probes, enzyme inhibitors, and other tools for biological target identification and validation.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) producing complex molecules for clients.

Basic Information

Product Name	2-(3,5-Difluorophenyl)Pyrimidine-5-Carboxylic Acid
CAS No.	933988-73-9
Molecular Formula	C11H6F2N2O2
Molecular Weight	236.18 g/mol
Synonyms	5-Pyrimidinecarboxylic acid, 2-(3,5-difluorophenyl)-; 2-(3,5-Difluorophenyl)-5-pyrimidinecarboxylic acid; 2-(3,5-Difluorophenyl)pyrimidine-5-carboxylic acid; 933988-73-9; 3,5-Difluorophenyl-pyrimidine-5-carboxylic acid; (3,5-Difluorophenyl)pyrimidine-5-carboxylic acid; 5-Carboxy-2-(3,5-difluorophenyl)pyrimidine
EINECS	Contact for details

Quality Control

Our 2-(3,5-Difluorophenyl)Pyrimidine-5-Carboxylic Acid is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our commitment to quality supports compliance with cGMP and ICH guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed and under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.