Description

5,6-Difluoroquinazolin-4(3H)-One is a high-value fluorinated quinazolinone derivative, a crucial advanced pharmaceutical intermediate. Its core value lies in its unique molecular scaffold, which is essential for synthesizing novel, potent small-molecule therapeutics targeting various disease pathways. This compound is primarily needed by research institutions and pharmaceutical companies engaged in drug discovery and development, particularly for oncology and kinase inhibitor programs.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of novel kinase inhibitors and targeted cancer therapies.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies to develop new chemical entities with optimized potency and selectivity.
• Organic Synthesis: Serves as a versatile precursor for constructing complex heterocyclic compounds in academic and industrial R&D.
• Biochemical Tool Compound: Potential use in developing probes for studying enzyme function and cellular signaling pathways.
• Agrochemical Research: Investigated as an intermediate for developing new active ingredients with enhanced properties.

Basic Information

Product Name	5,6-Difluoroquinazolin-4(3H)-One
CAS No.	933823-89-3
Molecular Formula	C8H4F2N2O
Molecular Weight	182.13 g/mol
Synonyms	5,6-Difluoro-3,4-dihydro-4-oxoquinazoline; 5,6-Difluoro-4(3H)-quinazolinone; 4(3H)-Quinazolinone, 5,6-difluoro-; 5,6-Difluoroquinazolin-4-ol; 933823-89-3; 5,6-Difluoro-4-hydroxyquinazoline
EINECS	Contact for details

Quality Control

Our 5,6-Difluoroquinazolin-4(3H)-One is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our commitment is to supply material that meets the stringent requirements of pharmaceutical R&D and cGMP starting material guidelines where applicable.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); the container must be kept tightly sealed in a dry environment to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms to reference spectrum
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.